VH replacement in mice and humans.

VH replacement in mice and humans. Research Abstract Details 

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VH replacement in mice and humans. Abstract Text:

Zhixin Zhang,

Heavy chain variable segment (V(H)) replacement refers to recombination activating gene (RAG) product-mediated secondary recombination between a previously rearranged V(H) gene and an upstream unrearranged V(H) gene. V(H) replacement was first observed in mouse pre-B cell lines and later demonstrated in knock-in mouse models carrying immunoglobulin heavy chain (IgH) genes encoding self-reactive or mono-specific antibodies or non-functional IgH rearrangements on both IgH alleles. Despite these findings, it is still difficult to find V(H) replacement intermediates during normal murine B cell development. In humans, ongoing V(H) replacement was found in a clonal B lineage EU12 cell line and in human bone marrow immature B cells. The identification of potential V(H) replacement products also suggested a potential contribution of V(H) replacement to the antibody repertoire. Here, I review the evidence for whether V(H) replacement genuinely offers an in vivo RAG-mediated recombinatorial mechanism to alter preformed IgH genes in mice and humans.

VH replacement in mice and humans. Publishing Authors By Initials

Z Zhang,

For similar genetic processes: recombination, genetic research abstracts see: genetic processes: recombination, genetic research

PUBMED ID PMID:

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VH replacement in mice and humans. Journal Published:

PUBLICATION TYPE: Review

Journal: Trends in immunology

VOLUME: 28

Page Numbers: 132-7

Journal Abbreviation: Trends Immunol.

ISSN: 1471-4906

DAY: 26

MONTH: 01

YEAR: 2007

VH replacement in mice and humans. Information

Number of References: 36

LANGUAGE: eng

NlmUniqueID: 100966032

VH replacement in mice and humans. Keywords Mesh Terms:

KEYWORDS: Recombination, Genetic

MESH TERMS: physiology

Chemical & Substance for Abstract: VH replacement in mice and humans. Information

Substance Name: RAG-1 protein

Registry Number: 128559-51-3

Grant and Affiliation Information for VH replacement in mice and humans.

AFFILIATION: Division of Developmental and Clinical Immunology, Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. zhixin.zhang@ccc.uab.edu

Country: England

AGENCY: United States NIAMS

GRANT: K01 AR 048592

ACRONYM: AR

MEDLINETA: Trends Immunol

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