Vg1 has specific processing requirements that restrict its action to body axis patterning centers.

Vg1 has specific processing requirements that restrict its action to body axis patterning centers. Research Abstract Details 

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Vg1 has specific processing requirements that restrict its action to body axis patterning centers. Abstract Text:

John Terrig Thomas,Malcolm Moos,John Terrig Thomas,Malcolm Moos,

Unlike most transforming growth factor-beta (TGF-beta) superfamily members, Vg1 has been shown not to produce gross phenotypic alterations in Xenopus embryos when overexpressed by mRNA injection. Experiments with artificial chimeric constructs and a recently identified second allele of Vg1 suggest that this may be due to unusually stringent requirements for proteolytic processing. We provide biological and biochemical evidence that cleavage by two distinct proteolytic enzymes is required for effective activation of Vg1. We demonstrate a tightly restricted overlap in expression patterns of Vg1 with the proteases required to release the mature peptide. The data presented may account for the long-standing observation that the vast majority of Vg1 protein, in vivo, is present in its unprocessed form. Taken together, these observations provide a plausible mechanism for local action of Vg1 consistent with requirements imposed by current models of pattern formation in the developing body axis.

Vg1 has specific processing requirements that restrict its action to body axis patterning centers. Publishing Authors By Initials

JT Thomas,M Moos,JT Thomas,M Moos,

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Vg1 has specific processing requirements that restrict its action to body axis patterning centers. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Developmental biology

VOLUME: 310

Page Numbers: 129-39

Journal Abbreviation: Dev. Biol.

ISSN: 0012-1606

DAY: 2

MONTH: 08

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 372762

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AFFILIATION: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD 20892, USA. john.thomas@fda.hhs.gov

Country: United States

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MEDLINETA: Dev Biol

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