Vertically aligned carbon nanofiber architecture as a multifunctional 3-D neural electrical interface.

Vertically aligned carbon nanofiber architecture as a multifunctional 3-D neural electrical interface. Research Abstract Details 

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Vertically aligned carbon nanofiber architecture as a multifunctional 3-D neural electrical interface. Abstract Text:

T D Barbara Nguyen-Vu,Hua Chen,Alan M Cassell,Russell J Andrews,M Meyyappan,Jun Li,

Developing biomaterial constructs that closely mimic the natural tissue microenvironment with its complex chemical and physical cues is essential for improving the function and reliability of implantable devices, especially those that require direct neural-electrical interfaces. Here we demonstrate that free-standing vertically aligned carbon nanofiber (VACNF) arrays can be used as a multifunctional 3-D brush-like nanoengineered matrix that interpenetrates the neuronal network of PC12 cells. We found that PC12 neuron cells cultured on VACNF substrates can form extended neural network upon proper chemical and biochemical modifications. The soft 3-D VACNF architecture provides a new platform to fine-tune the topographical, mechanical, chemical, and electrical cues at subcellular nanoscale. This new biomaterial platform can be used for both fundamental studies of material-cell interactions and the development of chronically stable implantable neural devices. Micropatterned multiplex VACNF arrays can be selectively controlled by electrical and electrochemical methods to provide localized stimulation with extraordinary spatiotemporal resolution. Further development of this technology may potentially result in a highly multiplex closed-loop system with multifunctions for neuromodulation and neuroprostheses.

Vertically aligned carbon nanofiber architecture as a multifunctional 3-D neural electrical interface. Publishing Authors By Initials

TD Nguyen-Vu,H Chen,AM Cassell,RJ Andrews,M Meyyappan,J Li,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research

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Vertically aligned carbon nanofiber architecture as a multifunctional 3-D neural electrical interface. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: IEEE transactions on bio-medical engineering

VOLUME: 54

Page Numbers: 1121-8

Journal Abbreviation:

ISSN: 0018-9294

DAY: 3

MONTH: Jun

YEAR: 2007

Vertically aligned carbon nanofiber architecture as a multifunctional 3-D neural electrical interface. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 12737

Vertically aligned carbon nanofiber architecture as a multifunctional 3-D neural electrical interface. Keywords Mesh Terms:

KEYWORDS: Rats

MESH TERMS: physiology

Chemical & Substance for Abstract: Vertically aligned carbon nanofiber architecture as a multifunctional 3-D neural electrical interface. Information

Substance Name: Nanotubes, Carbon

Registry Number: 0

Grant and Affiliation Information for Vertically aligned carbon nanofiber architecture as a multifunctional 3-D neural electrical interface.

AFFILIATION: NASA Ames Research Center, Moffett Field, CA 94035, USA. bnguyenv@stanford.edu

Country: United States

AGENCY: United States NINDS

GRANT: 5 R21 NS047721

ACRONYM: NS

MEDLINETA: IEEE Trans Biomed Eng

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