Ventromedial hypothalamic nucleus lesions disrupt olfactory mate recognition and receptivity in female ferrets.

Ventromedial hypothalamic nucleus lesions disrupt olfactory mate recognition and receptivity in female ferrets. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Ventromedial hypothalamic nucleus lesions disrupt olfactory mate recognition and receptivity in female ferrets. Abstract Text:

Daniel W Robarts,Michael J Baum,

Previous research showed that ferrets of both sexes rely on the perception of conspecifics' body odors to identify and motivate approach towards opposite-sex mating partners, and exposure to male body odors stimulated Fos expression in an olfactory projection circuit of female, but not male, ferrets that terminates in the ventromedial hypothalamic nucleus (VMH). We asked whether the female-typical preference of ferrets to approach male as opposed to female body odors in Y-maze tests would be disrupted by VMH lesions. Sexually experienced female ferrets were ovo-hysterectomized prior to receiving bilateral electrolytic lesions of the VMH, the preoptic area/anterior hypothalamus (POA/AH) or a sham operation. Subsequently, while receiving estradiol benzoate, females that received either complete or partial bilateral lesions of the VMH approached volatile odors from an anesthetized male on significantly fewer trials than females given POA/AH lesions or a sham operation. Both groups of ferrets with VMH lesion damage reliably discriminated between volatile anal scents as well as urinary odors from the 2 sexes in home cage habituation/dishabituation tests, suggesting that their odor-based sex discrimination remained intact. Females with complete bilateral VMH lesions showed significantly lower acceptance of neck gripping from a stimulus male (receptivity) and more aggression towards the male than all other groups of female subjects. Estrogen-sensitive neurons in the VMH appear to play a central role in female-typical neural processing of odor inputs leading to a preference to seek out a male sex partner, in addition to facilitating females' sexual receptivity.

Ventromedial hypothalamic nucleus lesions disrupt olfactory mate recognition and receptivity in female ferrets. Publishing Authors By Initials

DW Robarts,MJ Baum,

For similar hypothalamus, middle: ventromedial hypothalamic nucleus research abstracts see: hypothalamus, middle: ventromedial hypothalamic nucleus research

PUBMED ID PMID:

MEDLINE DATE:

Ventromedial hypothalamic nucleus lesions disrupt olfactory mate recognition and receptivity in female ferrets. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Hormones and behavior

VOLUME: 51

Page Numbers: 104-13

Journal Abbreviation:

ISSN: 0018-506X

DAY: 2

MONTH: 10

YEAR: 2006

Ventromedial hypothalamic nucleus lesions disrupt olfactory mate recognition and receptivity in female ferrets. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 217764

Ventromedial hypothalamic nucleus lesions disrupt olfactory mate recognition and receptivity in female ferrets. Keywords Mesh Terms:

KEYWORDS: Ventromedial Hypothalamic Nucleus

MESH TERMS: surgery

Chemical & Substance for Abstract: Ventromedial hypothalamic nucleus lesions disrupt olfactory mate recognition and receptivity in female ferrets. Information

Substance Name: Sex Attractants

Registry Number: 0

Grant and Affiliation Information for Ventromedial hypothalamic nucleus lesions disrupt olfactory mate recognition and receptivity in female ferrets.

AFFILIATION: Department of Biology, Boston University, Boston, MA 02215, USA.

Country: United States

AGENCY: United States NICHD

GRANT: HD21094

ACRONYM: HD

MEDLINETA: Horm Behav

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Ventromedial hypothalamic nucleus lesions disrupt olfactory mate recognition and receptivity in female ferrets Related Publications

• A lifetime in breast cancer research.
• Acute urinary tract infections in infants and children.
• Adjunctive self-hypnotic relaxation for outpatient medical procedures: a prospective randomized trial with women undergoing large core breast biopsy.
• Bilateral damage to the sexually dimorphic medial preoptic area/anterior hypothalamus of male ferrets causes a female-typical preference for and a hypothalamic Fos response to male body odors.
• Claudins 6, 9, and 13 are developmentally expressed renal tight junction proteins.
• Comparison of urinary odor-induced glomerular activation in the main olfactory bulb of aromatase knock-out and wild type female mice.
• Distinguishing among structural ensembles of the GB1 peptide: REMD simulations and NMR experiments.
• Galectin interactions with extracellular matrix and effects on cellular function.
• Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death.
• Gender differences in serotype 2 adeno-associated virus biodistribution after administration to rodent salivary glands.
• Happy anniversary.
• Insertional mutagenesis in gene therapy and stem cell biology.
• Mammalian animal models of psychosexual differentiation: when is 'translation' to the human situation possible?
• Mercury intoxication: lack of correlation between symptoms and levels.
• NMR shows hydrophobic interactions replace glycine packing in the triple helix at a natural break in the (Gly-X-Y)n repeat.
• Neuropsychological and neurophysiologic effects of carbamazepine and levetiracetam.
• O-glycosylation regulates LNCaP prostate cancer cell susceptibility to apoptosis induced by galectin-1.
• Ontogeny of NHE8 in the rat proximal tubule.
• Physical properties, durability, and energy-dissipation function of dual-density orthotic materials used in insoles for diabetic patients.
• Prenatal programming of rat proximal tubule Na+/H+ exchanger by dexamethasone.
• Prevention of Irradiation-induced Salivary Hypofunction by Microvessel Protection in Mouse Salivary Glands.
• Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways.
• Saliva can mediate HIV-1-specific antibody-dependent cell-mediated cytotoxicity.
• Sequence dependence of renucleation after a Gly mutation in model collagen peptides.
• Sexually dimorphic activation of the accessory, but not the main, olfactory bulb in mice by urinary volatiles.
• Toxicity and biodistribution of a first-generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery to a single rat submandibular gland.
• Vector design for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells.
• Ventromedial hypothalamic nucleus lesions disrupt olfactory mate recognition and receptivity in female ferrets.
• [Difficulty in swallowing]
• [Effect of certain substances on limits of the explosion of hydrogen-air mixture.]