Ventral striatal hyporesponsiveness during reward anticipation in attention-deficit/hyperactivity disorder.

Ventral striatal hyporesponsiveness during reward anticipation in attention-deficit/hyperactivity disorder. Research Abstract Details 

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Ventral striatal hyporesponsiveness during reward anticipation in attention-deficit/hyperactivity disorder. Abstract Text:

Anouk Scheres,Michael P Milham,Brian Knutson,Francisco Xavier Castellanos,

BACKGROUND: Although abnormalities in reward processing have been proposed to underlie attention-deficit/hyperactivity disorder (ADHD), this link has not been tested explicitly with neural probes. METHODS: This hypothesis was tested by using fMRI to compare neural activity within the striatum in individuals with ADHD and healthy controls during a reward-anticipation task that has been shown previously to produce reliable increases in ventral striatum activity in healthy adults and healthy adolescents. Eleven adolescents with ADHD (5 off medication and 6 medication-naïve) and 11 healthy controls (ages 12-17 y) were included. Groups were matched for age, gender, and intelligence quotient. RESULTS: We found reduced ventral striatal activation in adolescents with ADHD during reward anticipation, relative to healthy controls. Moreover, ventral striatal activation was negatively correlated with parent-rated hyperactive/impulsive symptoms across the entire sample. CONCLUSIONS: These findings provide neural evidence that symptoms of ADHD, and impulsivity or hyperactivity in particular, may involve diminished reward anticipation, in addition to commonly observed executive dysfunction.

Ventral striatal hyporesponsiveness during reward anticipation in attention-deficit/hyperactivity disorder. Publishing Authors By Initials

A Scheres,MP Milham,B Knutson,FX Castellanos,

For similar psychological phenomena and processes: mental processes: learning: reinforcement (psychology): reward research abstracts see: psychological phenomena and processes: mental processes: learning: reinforcement (psychology): reward research

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Ventral striatal hyporesponsiveness during reward anticipation in attention-deficit/hyperactivity disorder. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biological psychiatry

VOLUME: 61

Page Numbers: 720-4

Journal Abbreviation: Biol. Psychiatry

ISSN: 0006-3223

DAY: 1

MONTH: 09

YEAR: 2006

Ventral striatal hyporesponsiveness during reward anticipation in attention-deficit/hyperactivity disorder. Information

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LANGUAGE: eng

NlmUniqueID: 213264

Ventral striatal hyporesponsiveness during reward anticipation in attention-deficit/hyperactivity disorder. Keywords Mesh Terms:

KEYWORDS: Reward

MESH TERMS: physiology

Chemical & Substance for Abstract: Ventral striatal hyporesponsiveness during reward anticipation in attention-deficit/hyperactivity disorder. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Ventral striatal hyporesponsiveness during reward anticipation in attention-deficit/hyperactivity disorder.

AFFILIATION: Department of Psychology, University of Arizona, Tucson, Arizona 85721, USA. ascheres@u.arizona.edu

Country: United States

AGENCY: United States NIMH

GRANT: MH0660393

ACRONYM: MH

MEDLINETA: Biol Psychiatry

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