Ventilatory long-term facilitation in mice can be observed during both sleep and wake periods and depends on orexin.

Ventilatory long-term facilitation in mice can be observed during both sleep and wake periods and depends on orexin. Research Abstract Details 

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Ventilatory long-term facilitation in mice can be observed during both sleep and wake periods and depends on orexin. Abstract Text:

Jiro Terada,Akira Nakamura,Wei Zhang,Masashi Yanagisawa,Takayuki Kuriyama,Yasuichiro Fukuda,Tomoyuki Kuwaki,Jiro Terada,Akira Nakamura,Wei Zhang,Masashi Yanagisawa,Takayuki Kuriyama,Yasuichiro Fukuda,Tomoyuki Kuwaki,

Respiratory long-term facilitation (LTF) is a long-lasting (>1 h) augmentation of respiratory motor output that occurs even after cessation of hypoxic stimuli, is serotonin-dependent, and is thought to prevent sleep-disordered breathing such as sleep apnea. Raphe nuclei, which modulate several physiological functions through serotonin, receive dense projections from orexin-containing neurons in the hypothalamus. We examined possible contributions of orexin to ventilatory LTF by measuring respiration in freely moving prepro-orexin knockout mice (ORX-KO) and wild-type (WT) littermates before, during, and after exposure to intermittent hypoxia (IH; 5 x 5 min at 10% O(2)), sustained hypoxia (SH; 25 min at 10% O(2)), or sham stimulation. Respiratory data during quiet wakefulness (QW), slow wave sleep (SWS), and rapid-eye-movement sleep were separately calculated. Baseline ventilation before hypoxic stimulation and acute responses during stimulation did not differ between the ORX-KO and WT mice, although ventilation depended on vigilance state. Whereas the WT showed augmented minute ventilation (by 20.0 +/- 4.5% during QW and 26.5 +/- 5.3% during SWS; n = 8) for 2 h following IH, ORX-KO showed no significant increase (by -3.1 +/- 4.6% during QW and 0.3 +/- 5.2% during SWS; n = 8). Both genotypes showed no LTF after SH or sham stimulation. Sleep apnea indexes did not change following IH, even when LTF appeared in the WT mice. We conclude that LTF occurs during both sleep and wake periods, that orexin is necessary for eliciting LTF, and that LTF cannot prevent sleep apnea, at least in mice.

Ventilatory long-term facilitation in mice can be observed during both sleep and wake periods and depends on orexin. Publishing Authors By Initials

J Terada,A Nakamura,W Zhang,M Yanagisawa,T Kuriyama,Y Fukuda,T Kuwaki,J Terada,A Nakamura,W Zhang,M Yanagisawa,T Kuriyama,Y Fukuda,T Kuwaki,

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Ventilatory long-term facilitation in mice can be observed during both sleep and wake periods and depends on orexin. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of applied physiology (Bethesda, Md. : 198

VOLUME: 104

Page Numbers: 499-507

Journal Abbreviation: J. Appl. Physiol.

ISSN: 8750-7587

DAY: 21

MONTH: 11

YEAR: 2007

Ventilatory long-term facilitation in mice can be observed during both sleep and wake periods and depends on orexin. Information

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LANGUAGE: eng

NlmUniqueID: 8502536

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AFFILIATION: Dept. of Molecular & Integrative Physiology, Chiba Univ. Graduate School of Medicine, 1-8-1 Chuo-ku, Chiba 260-8670, Japan. kuwaki@faculty.chiba-u.jp).

Country: United States

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MEDLINETA: J Appl Physiol

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