VEGF-overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigration.

VEGF-overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigration. Research Abstract Details 

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VEGF-overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigration. Abstract Text:

Yaoming Wang,Kunlin Jin,Xiao Ou Mao,Lin Xie,Surita Banwait,Hugo H Marti,David A Greenberg,

New neurons are generated continuously in the subventricular zone and dentate gyrus of the adult brain. Neuropathologic processes, including cerebral ischemia, can enhance neurogenesis, as can growth factors and other physiologic stimuli. Vascular endothelial growth factor (VEGF) is an angiogenic and neuroprotective growth factor that can promote neurogenesis, but it is unknown whether VEGF can enhance migration of newborn neurons toward sites of ischemic injury, where they might be able to replace neurons that undergo ischemic death. In the present study we produced permanent focal cerebral ischemia in transgenic (Tg) mice that overexpress VEGF. Cell proliferation and neurogenesis were assessed with bromodeoxyuridine (Brdu) labeling and immunostaining for cell type-specific markers. In VEGF-Tg mice, brains examined 7-28 days after cerebral ischemia showed markedly increased subventricular zone (SVZ) neurogenesis, chains of neuroblasts extending from the SVZ to the peri-infarct cortex, and an increase in the number of newly generated cortical neurons at 14-28 days after ischemia. In concert with these effects, VEGF overexpression reduced infarct volume and improved postischemic motor function. These findings provide evidence that VEGF increases SVZ neurogenesis and neuromigration, consistent with a possible role in repair. Our data suggest that in addition to its neuroprotective effects, which are associated with improved outcome in the acute phase after cerebral ischemia, VEGF enhances postischemic neurogenesis, which could provide a therapeutic target for more chronic brain repair.

VEGF-overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigration. Publishing Authors By Initials

Y Wang,K Jin,XO Mao,L Xie,S Banwait,HH Marti,DA Greenberg,

For similar peptides: intercellular signaling peptides and proteins: angiogenic proteins: vascular endothelial growth factors: vascular endothelial growth factor a research abstracts see: peptides: intercellular signaling peptides and proteins: angiogenic proteins: vascular endothelial growth factors: vascular endothelial growth factor a research

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VEGF-overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigration. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of neuroscience research

VOLUME: 85

Page Numbers: 740-7

Journal Abbreviation: J. Neurosci. Res.

ISSN: 0360-4012

DAY: 3

MONTH: Mar

YEAR: 2007

VEGF-overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigration. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7600111

VEGF-overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigration. Keywords Mesh Terms:

KEYWORDS: Vascular Endothelial Growth Factor A

MESH TERMS: metabolism

Chemical & Substance for Abstract: VEGF-overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigration. Information

Substance Name: Phosphopyruvate Hydratase

Registry Number: EC 4.2.1.11

Grant and Affiliation Information for VEGF-overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigration.

AFFILIATION: Buck Institute for Age Research, Novato, California 94945, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS44921

ACRONYM: NS

MEDLINETA: J Neurosci Res

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