VEGF and VEGF receptors are differentially expressed in chondrocytes.

VEGF and VEGF receptors are differentially expressed in chondrocytes. Research Abstract Details 

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VEGF and VEGF receptors are differentially expressed in chondrocytes. Abstract Text:

Gilles Bluteau,Marion Julien,David Magne, Mallein-Gerin,Pierre Weiss,Guy Daculsi, Guicheux,

During long bone development, cartilage replacement by bone is governed in part by angiogenesis. Although it has been demonstrated that vascular endothelial growth factor (VEGF-A) is crucial during endochondral ossification, little is known about the involvement of the other VEGF family members. Thus, we examined the expression and production of these members on primary chondrocytes and ATDC5 chondrogenic cells. VEGF-A, VEGF-B, VEGF-C and VEGF-D were shown to be expressed and synthesized demonstrating that numerous angiogenic factors can be produced by chondrocytes. In ATDC5 VEGF-A, VEGF-B and VEGF-C were over-expressed in the presence of chondrogenic and bone morphogenetic protein (BMP)-2 treatment suggesting that these factors play an important role during chondrogenesis. In addition, neuropilin-1, VEGF receptor-2 and VEGF receptor-3 gene expression were observed with an increase in VEGF-R2 expression under chondrogenic and BMP-2 treatment, suggesting that VEGF proteins could act in an autocrine/paracrine manner in addition to their angiogenic function. In conclusion, we demonstrated for the first time that chondrocytes secreted the four members of the VEGF family. We also showed that VEGF-B, VEGF-C and VEGF-D were secreted as processed proteins. The up-regulation of VEGF-B and VEGF-C at the mRNA and protein levels under chondrogenic stimulation strongly suggests a major role for these proteins in growth plate physiology.

VEGF and VEGF receptors are differentially expressed in chondrocytes. Publishing Authors By Initials

G Bluteau,M Julien,D Magne,F Mallein-Gerin,P Weiss,G Daculsi,J Guicheux,

For similar peptides: intercellular signaling peptides and proteins: angiogenic proteins: vascular endothelial growth factors: vascular endothelial growth factor a research abstracts see: peptides: intercellular signaling peptides and proteins: angiogenic proteins: vascular endothelial growth factors: vascular endothelial growth factor a research

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VEGF and VEGF receptors are differentially expressed in chondrocytes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bone

VOLUME: 40

Page Numbers: 568-76

Journal Abbreviation: Bone

ISSN: 8756-3282

DAY: 3

MONTH: 11

YEAR: 2006

VEGF and VEGF receptors are differentially expressed in chondrocytes. Information

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LANGUAGE: eng

NlmUniqueID: 8504048

VEGF and VEGF receptors are differentially expressed in chondrocytes. Keywords Mesh Terms:

KEYWORDS: Vascular Endothelial Growth Factor A

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: VEGF and VEGF receptors are differentially expressed in chondrocytes. Information

Substance Name: Receptors, Vascular Endothelial Growth F

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for VEGF and VEGF receptors are differentially expressed in chondrocytes.

AFFILIATION: INSERM UMRS 791, University of Nantes, Laboratoire d'Ingénierie Ostéoarticulaire et Dentaire, LIOAD, School of Dental Surgery, 1 Place Alexis Ricordeau, Nantes Cedex 1, France.

Country: United States

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MEDLINETA: Bone

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