[Vector-mediated HER-2 RNA interference against HER-2-positive breast cancer]

[Vector-mediated HER-2 RNA interference against HER-2-positive breast cancer] Research Abstract Details 

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[Vector-mediated HER-2 RNA interference against HER-2-positive breast cancer] Abstract Text:

Xiao-qu Hu,Li Qin,Feng-xi Su,He-rui Yao,Ji-sheng Chen,Chang Gong,Ju-jiang Guo,Feng-yan Yu,Hai-xia Jia,

OBJECTIVE: To study the feasibility of vector-mediated RNA interference for HER-2-positive breast cancer therapy. METHODS: A plasmid vector capable of mediating HER-2 RNA interference was constructed, and HER-2-positive breast cancer cell line SKBR-3 was transfected with this constructed vector. The expression of HER-2 mRNA and protein was analyzed by RT-PCR and Western blotting, and the growth and apoptosis of SKBR-3 cells was analyzed after transfection. RESULTS: The expressions of HER-2 mRNA and HER-2 protein was downregulated in response to vector-mediated HER-2 RNA interference, which also resulted in tumor cell growth inhibition and increased number apoptotic cells. CONCLUSION: HER-2 is a good target for RNA interference and RNA interference targeting HER-2 can lead to HER-2 breast cancer cell apoptosis and growth inhibition.

[Vector-mediated HER-2 RNA interference against HER-2-positive breast cancer] Publishing Authors By Initials

XQ Hu,L Qin,FX Su,HR Yao,JS Chen,C Gong,JJ Guo,FY Yu,HX Jia,

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[Vector-mediated HER-2 RNA interference against HER-2-positive breast cancer] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nan fang yi ke da xue xue bao = Journal of Souther

VOLUME: 26

Page Numbers: 570-2

Journal Abbreviation: Nan Fang Yi Ke Da Xue Xue Bao

ISSN: 1673-4254

DAY: 9

MONTH: May

YEAR: 2006

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LANGUAGE: chi

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AFFILIATION: Center of Breast Cancer, Second Hospital of Sun Yat-sen University, Guangzhou 510272, China.

Country: China

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MEDLINETA: Nan Fang Yi Ke Da Xue Xue Bao

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