Vector autoregressive modeling analysis of frequently sampled oral glucose tolerance test results. 2. Insulin resistance and secretion after gastrectomy.

Vector autoregressive modeling analysis of frequently sampled oral glucose tolerance test results. 2. Insulin resistance and secretion after gastrectomy. Research Abstract Details 

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Vector autoregressive modeling analysis of frequently sampled oral glucose tolerance test results. 2. Insulin resistance and secretion after gastrectomy. Abstract Text:

Using the method of vector autoregressive modeling (VAR) analysis of frequently sampled oral glucose tolerance test (OGTT) results, we evaluated abnormalities in the feedback relationships between plasma glucose and insulin in gastrectomized patients to assess insulin secretion capacity and insulin resistance following gastrectomy. VAR modeling analysis was applied to the plasma glucose and insulin level data from the frequently-sampled 75g-OGTT results of 38 subjects who had undergone total or subtotal gastrectomy and 977 controls without gastrectomy. After gastrectomy, the predicted response of insulin to a glucose challenge was excessive in normal subjects and those with slightly impaired glucose tolerance. Furthermore, the glucose response to insulin was clearly positive in gastrectomized subjects with moderately to severely impaired glucose tolerance, i.e., diabetics, indicating strong insulin resistance. The insulin resistance in this situation cannot be explained by decreased peripheral glucose disposal. Our results suggest that the lowered glucose tolerance which follows gastrectomy results from disturbance of the hormonal relationship between pancreas and intestine (entero-insular axis), which causes increased intestinal glucose absorption, and the insulin resistance which occurs in response to hyperinsulinemia in patients with normal fasting plasma glucose. Disturbance of the entero-insular axis may cause not only increased glucose absorption but also hyperglucagonemia, both of which contribute to hyperglycemia in diabetic patients after gastrectomy.

Vector autoregressive modeling analysis of frequently sampled oral glucose tolerance test results. 2. Insulin resistance and secretion after gastrectomy. Publishing Authors By Initials

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Vector autoregressive modeling analysis of frequently sampled oral glucose tolerance test results. 2. Insulin resistance and secretion after gastrectomy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Keio journal of medicine

VOLUME: 47

Page Numbers: 78-84

Journal Abbreviation: Keio J Med

ISSN: 0022-9717

DAY: 7

MONTH: Jun

YEAR: 1998

Vector autoregressive modeling analysis of frequently sampled oral glucose tolerance test results. 2. Insulin resistance and secretion after gastrectomy. Information

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LANGUAGE: eng

NlmUniqueID: 376354

Vector autoregressive modeling analysis of frequently sampled oral glucose tolerance test results. 2. Insulin resistance and secretion after gastrectomy. Keywords Mesh Terms:

KEYWORDS: Regression Analysis

MESH TERMS: physiology

Chemical & Substance for Abstract: Vector autoregressive modeling analysis of frequently sampled oral glucose tolerance test results. 2. Insulin resistance and secretion after gastrectomy. Information

Substance Name: Insulin

Registry Number: 11061-68-0

Grant and Affiliation Information for Vector autoregressive modeling analysis of frequently sampled oral glucose tolerance test results. 2. Insulin resistance and secretion after gastrectomy.

AFFILIATION: Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.

Country: JAPAN

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MEDLINETA: Keio J Med

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