Vasomotor effects of noradrenaline, acetylcholine, histamine, 5-hydroxytryptamine and bradykinin on snake (Trimeresurus flavoviridis) basilar arteries.

Vasomotor effects of noradrenaline, acetylcholine, histamine, 5-hydroxytryptamine and bradykinin on snake (Trimeresurus flavoviridis) basilar arteries. Research Abstract Details 

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Vasomotor effects of noradrenaline, acetylcholine, histamine, 5-hydroxytryptamine and bradykinin on snake (Trimeresurus flavoviridis) basilar arteries. Abstract Text:

Narihiro Yoshinaga,Tadatune Okuno,Yutaka Watanabe,Tsukasa Matsumoto,Mitsuya Shiraishi,Takeshi Obi,Akira Yabuki,Atsushi Miyamoto,Narihiro Yoshinaga,Tadatune Okuno,Yutaka Watanabe,Tsukasa Matsumoto,Mitsuya Shiraishi,Takeshi Obi,Akira Yabuki,Atsushi Miyamoto,Narihiro Yoshinaga,Tadatune Okuno,Yutaka Watanabe,Tsukasa Matsumoto,Mitsuya Shiraishi,Takeshi Obi,Akira Yabuki,Atsushi Miyamoto,

We investigated the responsiveness of basilar arterial rings isolated from snakes to noradrenaline (NA), acetylcholine (ACh), histamine (His), 5-hydroxytryptamine (5-HT), mammalian bradykinin (BK) and rattlesnake BK. We also examined whether endothelial cells were involved in the responsiveness to ACh, BK, rattlesnake BK and in their resting vascular tone. NA and 5-HT induced concentration-dependent contractions. The cumulative concentration response curves of NA and 5-HT were shifted to the right in parallel by phentolamine (an alpha antagonist) and methiothepin (a 5-HT(1) and 5-HT(2) antagonist), respectively. However, ketanserin (a 5-HT(2) antagonist) had no effect on the cumulative concentration response curve of 5-HT. His, ACh, BK and rattlesnake BK had no effect on resting vascular tone; however, rattlesnake BK and sodium nitroprusside relaxed arteries precontracted by 5-HT. The rattlesnake BK-induced relaxations were almost abolished by L-nitro arginine (L-NA, a nitric oxide synthase inhibitor). L-NA and indomethacin (a cyclooxygenase inhibitor) had no effect on resting vascular tone or on precontracted arteries. These results suggest that alpha and 5-HT(1) receptor subtypes might be important in arterial contraction. Endothelial cells might play an important role in the responsiveness of snake basilar arteries to rattlesnake BK, but they might not be involved in the responsiveness to ACh, BK and in resting vascular tone.

Vasomotor effects of noradrenaline, acetylcholine, histamine, 5-hydroxytryptamine and bradykinin on snake (Trimeresurus flavoviridis) basilar arteries. Publishing Authors By Initials

N Yoshinaga,T Okuno,Y Watanabe,T Matsumoto,M Shiraishi,T Obi,A Yabuki,A Miyamoto,N Yoshinaga,T Okuno,Y Watanabe,T Matsumoto,M Shiraishi,T Obi,A Yabuki,A Miyamoto,N Yoshinaga,T Okuno,Y Watanabe,T Matsumoto,M Shiraishi,T Obi,A Yabuki,A Miyamoto,

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Vasomotor effects of noradrenaline, acetylcholine, histamine, 5-hydroxytryptamine and bradykinin on snake (Trimeresurus flavoviridis) basilar arteries. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Comparative biochemistry and physiology. Toxicolog

VOLUME: 146

Page Numbers: 478-83

Journal Abbreviation: Comp. Biochem. Physiol. C Toxi

ISSN: 1532-0456

DAY: 9

MONTH: 06

YEAR: 2007

Vasomotor effects of noradrenaline, acetylcholine, histamine, 5-hydroxytryptamine and bradykinin on snake (Trimeresurus flavoviridis) basilar arteries. Information

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LANGUAGE: eng

NlmUniqueID: 100959500

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Grant and Affiliation Information for Vasomotor effects of noradrenaline, acetylcholine, histamine, 5-hydroxytryptamine and bradykinin on snake (Trimeresurus flavoviridis) basilar arteries.

AFFILIATION: Department of Veterinary Pharmacology, Faculty of Agriculture, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan.

Country: United States

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MEDLINETA: Comp Biochem Physiol C Toxicol

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