Vasoactive intestinal peptide causes marked cephalic vasodilation, but does not induce migraine.

Vasoactive intestinal peptide causes marked cephalic vasodilation, but does not induce migraine. Research Abstract Details 

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Vasoactive intestinal peptide causes marked cephalic vasodilation, but does not induce migraine. Abstract Text:

A Rahmann,T Wienecke,J M Hansen,J Fahrenkrug,J Olesen,M Ashina,

We hypothesized that intravenous infusion of the parasympathetic transmitter, vasoactive intestinal peptide (VIP), might induce migraine attacks in migraineurs. Twelve patients with migraine without aura were allocated to receive 8 pmol kg(-1) min(-1) VIP or placebo in a randomized, double-blind crossover study. Headache was scored on a verbal rating scale (VRS), mean blood flow velocity in the middle cerebral artery (V(mean MCA)) was measured by transcranial Doppler ultrasonography, and diameter of the superficial temporal artery (STA) by high-frequency ultrasound. None of the subjects reported a migraine attack after VIP infusion. VIP induced a mild immediate headache (maximum 2 on VRS) compared with placebo (P = 0.005). Three patients reported delayed headache (3-11 h after infusion) after VIP and two after placebo (P = 0.89). V(mean MCA) decreased (16.3 +/- 5.9%) and diameter of STA increased significantly after VIP (45.9 +/- 13.9%). VIP mediates a marked dilation of cranial arteries, but does not trigger migraine attacks in migraineurs. These data provide further evidence against a purely vascular origin of migraine.

Vasoactive intestinal peptide causes marked cephalic vasodilation, but does not induce migraine. Publishing Authors By Initials

A Rahmann,T Wienecke,JM Hansen,J Fahrenkrug,J Olesen,M Ashina,

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Vasoactive intestinal peptide causes marked cephalic vasodilation, but does not induce migraine. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cephalalgia : an international journal of headache

VOLUME: 28

Page Numbers: 226-36

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ISSN: 1468-2982

DAY: 7

MONTH: Mar

YEAR: 2008

Vasoactive intestinal peptide causes marked cephalic vasodilation, but does not induce migraine. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Vasoactive intestinal peptide causes marked cephalic vasodilation, but does not induce migraine.

AFFILIATION: Danish Headache Centre, Department of Neurology, Glostrup Hospital, Copenhagen, Denmark. rahmana@uni-muenster.de

Country: England

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MEDLINETA: Cephalalgia

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