Vascularized composite islet-kidney transplantation in a miniature swine model.

Vascularized composite islet-kidney transplantation in a miniature swine model. Research Abstract Details 

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Vascularized composite islet-kidney transplantation in a miniature swine model. Abstract Text:

Prashanth Vallabhajosyula,Adam Griesemer,Kazuhiko Yamada,David H Sachs,

Previous work from this laboratory has demonstrated that transplantation of allogeneic thymic tissue as part of a composite vascularized graft is far more successful in terms of both engraftment and long-term survival than transplantation of thymic tissue or cells alone. We have subsequently extended this concept to transplantation of allogeneic islets, comparing survival of islet cell suspensions to that of vascularized composite islet-kidneys (IK), prepared by injection of autologous islets underneath the renal capsule 2-3 months prior to allogeneic transplantation of the composite organ. We have utilized partially inbred miniature swine with defined MHC loci as the experimental large animals for this study, permitting reproducible transplantation across specific MHC barriers. Composite IK have been transplanted successfully across minor and full MHC mismatch barriers, using treatment regimens previously demonstrated to induce long-term tolerance of kidney allografts across these barriers. IK allografts containing > or =5000 islet equivalents (IE)/kg recipient body weight were found capable of reversing surgically induced diabetes, while injection of comparable numbers of purified islets via the portal vein or under the renal capsule did not. Studies are also being directed toward preparation of autologous "thymo-isletkidneys" (TIK), for potential use as xenografts, in which the thymic component is intended to induce tolerance and the islets to reverse diabetic hyperglycemia. The use of both types of composite organ transplants may eventually be applicable to the treatment of type I diabetic patients suffering from end-stage diabetic nephropathy.

Vascularized composite islet-kidney transplantation in a miniature swine model. Publishing Authors By Initials

P Vallabhajosyula,A Griesemer,K Yamada,DH Sachs,

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

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Vascularized composite islet-kidney transplantation in a miniature swine model. Journal Published:

PUBLICATION TYPE: Review

Journal: Cell biochemistry and biophysics

VOLUME: 48

Page Numbers: 201-7

Journal Abbreviation: Cell Biochem. Biophys.

ISSN: 1085-9195

DAY: 3

MONTH: 12

YEAR: 2007

Vascularized composite islet-kidney transplantation in a miniature swine model. Information

Number of References: 31

LANGUAGE: eng

NlmUniqueID: 9701934

Vascularized composite islet-kidney transplantation in a miniature swine model. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: methods

Chemical & Substance for Abstract: Vascularized composite islet-kidney transplantation in a miniature swine model. Information

Substance Name: Immunosuppressive Agents

Registry Number: 0

Grant and Affiliation Information for Vascularized composite islet-kidney transplantation in a miniature swine model.

AFFILIATION: Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: 1R33DK069827

ACRONYM: DK

MEDLINETA: Cell Biochem Biophys

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