Vascularization into a porous sponge by sustained release of basic fibroblast growth factor.

Vascularization into a porous sponge by sustained release of basic fibroblast growth factor. Research Abstract Details 

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Vascularization into a porous sponge by sustained release of basic fibroblast growth factor. Abstract Text:

Y Tabata,M Miyao,M Yamamoto,Y Ikada,

Vascularization into a poly(vinyl alcohol) (PVA) sponge was investigated using basic fibroblast growth factor (bFGF). This growth factor was impregnated into biodegradable gelatin microspheres for its sustained release and then the bFGF-containing microspheres or free bFGF were incorporated into PVA sponges. Following subcutaneous implantation into the back of mice, the bFGF-containing gelatin microspheres induced vascularization in and around the sponge to a significantly greater extent than that of free bFGF from 3 days after implantation. Significant ingrowth of fibrous tissue into the sponge was also observed when bFGF-containing microspheres were added to the sponge in contrast to free bFGF. Tissue ingrowth occurred into the deeper portion of the sponge over time while it accompanied formation of new capillaries. Empty gelatin microspheres had no effect on vascularization and the level of fibrous tissue ingrowth into the sponge was similar to that of the control group. It was concluded that incorporation of gelatin microspheres containing bFGF into the PVA sponge was effective in prevascularization of the sponge pores.

Vascularization into a porous sponge by sustained release of basic fibroblast growth factor. Publishing Authors By Initials

Y Tabata,M Miyao,M Yamamoto,Y Ikada,

For similar equipment and supplies: surgical equipment: surgical sponges research abstracts see: equipment and supplies: surgical equipment: surgical sponges research

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Vascularization into a porous sponge by sustained release of basic fibroblast growth factor. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 10

Page Numbers: 957-68

Journal Abbreviation:

ISSN: 0920-5063

DAY: 20

MONTH: 02

YEAR: 1999

Vascularization into a porous sponge by sustained release of basic fibroblast growth factor. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9007393

Vascularization into a porous sponge by sustained release of basic fibroblast growth factor. Keywords Mesh Terms:

KEYWORDS: Surgical Sponges

MESH TERMS: drug effects

Chemical & Substance for Abstract: Vascularization into a porous sponge by sustained release of basic fibroblast growth factor. Information

Substance Name: Gelatin

Registry Number: 9000-70-8

Grant and Affiliation Information for Vascularization into a porous sponge by sustained release of basic fibroblast growth factor.

AFFILIATION: Institute for Frontier Medical Sciences, Kyoto University, Japan.

Country: NETHERLANDS

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MEDLINETA: J Biomater Sci Polym Ed

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