Vascular expression of germinal ACE fails to maintain normal blood pressure in ACE-/- mice.

Vascular expression of germinal ACE fails to maintain normal blood pressure in ACE-/- mice. Research Abstract Details 

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Vascular expression of germinal ACE fails to maintain normal blood pressure in ACE-/- mice. Abstract Text:

Sean P Kessler,Preenie deS Senanayake,Christina Gaughan,Ganes C Sen,

Maintenance of normal blood pressure is critical for preserving the integrity of the cardiovascular system. Angiotensin 1-converting enzyme (ACE) regulates normal blood pressure and fluid homeostasis through its action in the renin-angiotensin-aldosterone system (RAAS) and the renal tubuloglomerular feedback response. Although the two structurally related isozymic forms of ACE both generate the vasoactive octapeptide angiotensin II (Ang II) with equal efficiency, both are expressed in a nonoverlapping tissue-restricted fashion. To discriminate the precise physiological role of each ACE in its requisite tissue in vivo, we expressed one ACE isoform exclusively in a single cell type of an Ace null mouse. Previously, we demonstrated that vascular endothelial cell-specific expression of transgenic somatic ACE (sACE) could restore normal blood pressure of Ace-null mice. In this current study, we expressed germinal ACE (gACE) in the vascular endothelial cells of the Ace null mouse. These mice exhibited correct renal structure, renal function, and normal growth rates. Although the mice had elevated levels of gACE bound to vascular endothelial cells and high levels of gACE and Ang II in the circulating serum, blood pressure was restored only partially. This study demonstrated that gACE, even when expressed in the vasculature, could not functionally substitute for sACE.

Vascular expression of germinal ACE fails to maintain normal blood pressure in ACE-/- mice. Publishing Authors By Initials

SP Kessler,P Senanayake,C Gaughan,GC Sen,

For similar enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: exopeptidases: peptidyl-dipeptidase a research abstracts see: enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: exopeptidases: peptidyl-dipeptidase a research

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Vascular expression of germinal ACE fails to maintain normal blood pressure in ACE-/- mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The FASEB journal : official publication of the Fe

VOLUME: 21

Page Numbers: 156-66

Journal Abbreviation: FASEB J.

ISSN: 1530-6860

DAY: 29

MONTH: 11

YEAR: 2006

Vascular expression of germinal ACE fails to maintain normal blood pressure in ACE-/- mice. Information

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LANGUAGE: eng

NlmUniqueID: 8804484

Vascular expression of germinal ACE fails to maintain normal blood pressure in ACE-/- mice. Keywords Mesh Terms:

KEYWORDS: Peptidyl-Dipeptidase A

MESH TERMS: physiology

Chemical & Substance for Abstract: Vascular expression of germinal ACE fails to maintain normal blood pressure in ACE-/- mice. Information

Substance Name: Peptidyl-Dipeptidase A

Registry Number: EC 3.4.15.1

Grant and Affiliation Information for Vascular expression of germinal ACE fails to maintain normal blood pressure in ACE-/- mice.

AFFILIATION: Department of Molecular Genetics, Lerner Research Institute, 9500 Euclid Ave., Cleveland, Ohio 44195, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL-48258

ACRONYM: HL

MEDLINETA: FASEB J

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