Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition.

Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Abstract Text:

Katherine Holmes,Owain Ll Roberts,Angharad M Thomas,Michael J Cross,Katherine Holmes,Owain Ll Roberts,Angharad M Thomas,Michael J Cross,

Vascular endothelial growth factors (VEGFs) regulate vascular development, angiogenesis and lymphangiogenesis by binding to a number of receptors. VEGFR-1 is required for the recruitment of haematopoietic stem cells and the migration of monocytes and macrophages, VEGFR-2 regulates vascular endothelial function and VEGFR-3 regulates lymphatic endothelial cell function. Over the last decade, considerable progress has been made in delineating the VEGFR-2 specific intracellular signalling cascades leading to proliferation, migration, survival and increased permeability, each of which contributes to the angiogenic response. Furthermore, therapeutic inhibition of VEGFR-2 action is now having an impact in the clinic for the treatment of a number of diseases.

Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Publishing Authors By Initials

K Holmes,OL Roberts,AM Thomas,MJ Cross,K Holmes,OL Roberts,AM Thomas,MJ Cross,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Journal Published:

PUBLICATION TYPE: Review

Journal: Cellular signalling

VOLUME: 19

Page Numbers: 2003-12

Journal Abbreviation: Cell. Signal.

ISSN: 0898-6568

DAY: 12

MONTH: 06

YEAR: 2007

Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Information

Number of References: 112

LANGUAGE: eng

NlmUniqueID: 8904683

Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition.

AFFILIATION: North West Cancer Research Fund Institute, School of Biological Sciences, College of Natural Sciences, University of Wales, Bangor, UK.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Cell Signal

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition Related Publications

• A Viral Envelope as a Vehicle for Tracer, Drug, and Gene Delivery: Initial Biodistribution Study Using PET Imaging.
• Angiostatin and endostatin inhibit endothelial cell migration in response to FGF and VEGF without interfering with specific intracellular signal transduction pathways.
• Apoptosis-associated changes in the glycerophospholipid composition of hematopoietic progenitor cells monitored by 31P NMR spectroscopy and MALDI-TOF mass spectrometry.
• Backbone structure of the amantadine-blocked trans-membrane domain M2 proton channel from Influenza A virus.
• Community sexually transmitted infection services are good enough: a qualitative study of clients' experiences.
• Consequences of telomere shortening at an active VSG expression site in telomerase-deficient Trypanosoma brucei.
• Cyclin and cyclin-dependent kinase substrate requirements for preventing rereplication reveal the need for concomitant activation and inhibition.
• Detection of the Ki-67 antigen in fixed and wax-embedded sections with the monoclonal antibody MIB1. D. McCormick H. Chong, C. Hobbs, C. Datta & P. A. Hall. Histopathology 1993; 22; 355-360.
• Diagnostic and therapeutic management of eosinophilia-associated chronic myeloproliferative disorders.
• Diet and risk of multiple myeloma in Connecticut women.
• Endovascular treatment of vertebral artery-origin and innominate/subclavian disease: indications and technique.
• Expert commentary.
• Expert commentary.
• Further evidence of attention bias for negative information in late life depression.
• Genome-wide screening of alpha-tocopherol sensitive genes in heart tissue from alpha-tocopherol transfer protein null mice (ATTP(-/-)).
• Higher IgG index found in African Americans versus Caucasians with multiple sclerosis.
• Histone modifications in Trypanosoma brucei.
• Laser hair removal.
• Maintaining eye care services during times of conflict.
• Methylation-sensitive high-resolution melting-curve analysis of the SNRPN gene as a diagnostic screen for Prader-Willi and Angelman syndromes.
• Morbidity profiles of patients consulting during influenza and respiratory syncytial virus active periods.
• Percutaneous absorption of topically applied NSAIDS and other compounds: Role of solute properties, skin physiology and delivery systems.
• Protective role of Bacillus anthracis exosporium in macrophage-mediated killing by nitric oxide.
• Role of Bacillus anthracis spore structures in macrophage cytokine responses.
• Salivary hormones and parturition in healthy, primigravid women.
• Single-institution experience with matrix coils in the treatment of intracranial aneurysms: comparison with same-center outcomes with the use of platinum coils.
• The chemical and dynamical influence of the anti-viral drug amantadine on the M2 proton channel transmembrane domain.
• Uniformly aligned full-length membrane proteins in liquid crystalline bilayers for structural characterization.
• Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition.
• [Application of denaturing high performance liquid chromatography to mutation detection of the c-kit gene in mastocytosis]