Vascular endothelial growth factor gene expression in patients' ischemic skeletal muscle with diabetic foot.

Vascular endothelial growth factor gene expression in patients' ischemic skeletal muscle with diabetic foot. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Vascular endothelial growth factor gene expression in patients' ischemic skeletal muscle with diabetic foot. Abstract Text:

Zheng Wang,Jiwei Zhang,Baigen Zhang,

OBJECTIVE: To investigate the relationship between the endogenous vascular endothelial growth factor (VEGF) gene expression in diabetics' calf ischemic skeletal muscle and the pathogeny of diabetic foot. METHODS: Twenty-four patients (33 limbs) were divided into 3 groups: diabetes mellitus (DM) without lower extremity ischemia (n = 5) (10 limbs); arteriosclerosis obliterans (ASO) without diabetes mellitus (n = 10) (13 limbs); diabetic lower limb arteriosclerosis obliterans (DLASO) (n = 9) (10 limbs). Control group consisted of normal volunteers (NOR) (n = 5) (10 limbs). The calf skeletal muscle tissue was obtained through muscle biopsy. RT-PCR was applied to determine the expression of hVEGF165mRNA. RESULTS: There was no expression in the calf skeletal muscle tissue of normal volunteers and DM. The calf skeletal muscle tissue in DLASO had the expression of hVEGF165mRNA (0.021 +/- 0.013) micro g, but obviously lower than ASO (0.133 +/- 0.024) micro g, (t = 13.32, P < 0.01). CONCLUSIONS: The endogenous VEGF gene expression in ischemic lower extremity of DLASO is obviously lower than that of ASO. It is the important endogenic cause of the genesis and development of diabetic foot ulcer.

Vascular endothelial growth factor gene expression in patients' ischemic skeletal muscle with diabetic foot. Publishing Authors By Initials

Z Wang,J Zhang,B Zhang,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Vascular endothelial growth factor gene expression in patients' ischemic skeletal muscle with diabetic foot. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua yu fang yi xue za zhi [Chinese journal of

VOLUME: 36

Page Numbers: 505-7

Journal Abbreviation: Zhonghua Yu Fang Yi Xue Za Zhi

ISSN: 0253-9624

DAY: 4

MONTH: Dec

YEAR: 2002

Vascular endothelial growth factor gene expression in patients' ischemic skeletal muscle with diabetic foot. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7904962

Vascular endothelial growth factor gene expression in patients' ischemic skeletal muscle with diabetic foot. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Vascular endothelial growth factor gene expression in patients' ischemic skeletal muscle with diabetic foot. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Vascular endothelial growth factor gene expression in patients' ischemic skeletal muscle with diabetic foot.

AFFILIATION: Department of Vascular Surgery, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Zhonghua Yu Fang Yi Xue Za Zhi

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Vascular endothelial growth factor gene expression in patients' ischemic skeletal muscle with diabetic foot Related Publications

• A comparative study on the intercuspal occlusion among TMD patients, malocclusion patients and university students.
• Effect of retinoblastoma gene on human osteosarcoma cell line OS732.
• Enhanced antioxidant and cytoprotective abilities of vitamin E succinate is associated with a rapid uptake advantage in rat hepatocytes and mitochondria.
• Intervention by azithromycin on bleomycin-induced lung injury in rats and its mechanisms.
• Method development of adsorbed stationary phase open tubular capillary electrochromatography.
• Supercritical fluid CO2 extraction of colchicine from colchicine Autumnele liliaceae.
• Vascular endothelial growth factor gene expression in patients' ischemic skeletal muscle with diabetic foot.
• [A case of hypodermiasis with empyema]
• [Analysis of hepatitis G virus genotypes in some areas of China]
• [Autologous dendritic cells eliciting cytotoxicity of bone marrow cells against chronic granulocytic leukemia]
• [Changes of human recombination bone morphogenetic protein-2 in bone and marrow in tail suspended rats]
• [Cloning of the mouse Doc-1R gene by genomic walking]
• [Construction of recombinant adenoviruses carrying human urokinase-type plasminogen activator and its expression in hepatic stellate cells in vitro]
• [Effect of inhibition of telomerase activity on cisplatin-induced apoptosis in K562 cells]
• [Effects of electrical stimulation of lateral hypothalamic area on gastric ischemia-reperfusion injury in rats]
• [Fatal complications in traffic accident injury]
• [Indomethacin induces apoptosis of K562 cells through activation of caspases and elevation of intracellular free calcium]
• [Infection and replication of hepatitis B virus and its clearance mechanism: an overview]
• [Mechanisms underlying dopaminergic neurotoxicity in ischemic cerebral damage]
• [Physiological and pathologic implications for zero-stress state of the esophagus]
• [Protein kinases and Alzheimer's disease]
• [Retroperitoneal laparoscopic unroofing of renal cyst: use of close method]
• [Risk of leukemia among medical X-ray workers in China between 1950 and 1995]
• [Studies on association between lipoprotein lipase gene polymorphisms of Pvu II site and hypertriglyceridemics in Chinese]
• [Study on automatic segmentation of color images applied to blood cells]
• [Study on high performance liquid chromatography/indirect photometric detection of fosfomycin with acridine as detection reagent]
• [Study on the application of number fluorescence density in detecting autoantibodies titer]
• [The effects of surface morphology of calcium phosphate ceramics on apatite formation in dynamic SBF]
• [Transforming growth factor beta(1) and bone morphogenetic protein 2 induce the differentiation of odontoblasts in vitro]
• [Vector propagation algorithm based ECG simulation of bundle branch block]