Vascular endothelial growth factor expression in arthritic joint is regulated by SAF-1 transcription factor.

Vascular endothelial growth factor expression in arthritic joint is regulated by SAF-1 transcription factor. Research Abstract Details 

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Vascular endothelial growth factor expression in arthritic joint is regulated by SAF-1 transcription factor. Abstract Text:

Bimal K Ray,Arvind Shakya,Alpana Ray,

Vascular endothelial growth factor (VEGF) plays an important role in the pathogenesis of arthritis by promoting angiogenesis in the synovial joint and infiltration of inflammatory cells in the synovial joint. Although ample information has been obtained on the mechanism of VEGF regulation during cancer and hypoxic condition, less is known about the control of VEGF expression during arthritis. From the studies on the experimentally induced arthritis in a transgenic mouse model that overexpresses a transcription factor, serum amyloid A activating factor-1 (SAF-1), leading to markedly higher levels of angiogenesis, synovial inflammation, and inflammatory cell infiltration, we have identified a novel mechanism of VEGF regulation. We present molecular evidence that VEGF expression is increased in SAF-1-transgenic mice and that SAF-1 induces VEGF transcription by directly binding to its promoter. Deletion of SAF-1 binding elements from the VEGF promoter as well as knockdown of endogenous SAF-1 markedly inhibited IL-1beta- and TGF-beta-mediated induction of VEGF expression in chondrocyte cells. By chromatin immunoprecipitation assay, in vivo, markedly higher levels of SAF-1 interaction with the VEGF promoter was detected in the cartilage tissues of arthritic mice as well as human osteoarthritic patients. Together, these results provide a new insight into the molecular mechanism of VEGF expression.

Vascular endothelial growth factor expression in arthritic joint is regulated by SAF-1 transcription factor. Publishing Authors By Initials

BK Ray,A Shakya,A Ray,

For similar peptides: intercellular signaling peptides and proteins: angiogenic proteins: vascular endothelial growth factors: vascular endothelial growth factor a research abstracts see: peptides: intercellular signaling peptides and proteins: angiogenic proteins: vascular endothelial growth factors: vascular endothelial growth factor a research

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Vascular endothelial growth factor expression in arthritic joint is regulated by SAF-1 transcription factor. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 178

Page Numbers: 1774-82

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 1

MONTH: Feb

YEAR: 2007

Vascular endothelial growth factor expression in arthritic joint is regulated by SAF-1 transcription factor. Information

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LANGUAGE: eng

NlmUniqueID: 2985117

Vascular endothelial growth factor expression in arthritic joint is regulated by SAF-1 transcription factor. Keywords Mesh Terms:

KEYWORDS: Vascular Endothelial Growth Factor A

MESH TERMS: genetics

Chemical & Substance for Abstract: Vascular endothelial growth factor expression in arthritic joint is regulated by SAF-1 transcription factor. Information

Substance Name: c-MYC-associated zinc finger protein

Registry Number: 0

Grant and Affiliation Information for Vascular endothelial growth factor expression in arthritic joint is regulated by SAF-1 transcription factor.

AFFILIATION: Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: AR48762

ACRONYM: AR

MEDLINETA: J Immunol

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