Vascular endothelial growth factor-C and its receptor VEGFR-3 in non-small-cell lung cancer: concurrent expression in cancer cells from primary tumour and metastatic lymph node.

Vascular endothelial growth factor-C and its receptor VEGFR-3 in non-small-cell lung cancer: concurrent expression in cancer cells from primary tumour and metastatic lymph node. Research Abstract Details 

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Vascular endothelial growth factor-C and its receptor VEGFR-3 in non-small-cell lung cancer: concurrent expression in cancer cells from primary tumour and metastatic lymph node. Abstract Text:

Pierre Saintigny,Marianne Kambouchner,Madani Ly, Gomes,Odile Sainte-Catherine,Roger Vassy, Czernichow,Philippe Letoumelin,Jean-Luc Breau, Bernaudin,Michel Kraemer,Pierre Saintigny,Marianne Kambouchner,Madani Ly, Gomes,Odile Sainte-Catherine,Roger Vassy, Czernichow,Philippe Letoumelin,Jean-Luc Breau, Bernaudin,Michel Kraemer,Pierre Saintigny,Marianne Kambouchner,Madani Ly, Gomes,Odile Sainte-Catherine,Roger Vassy, Czernichow,Philippe Letoumelin,Jean-Luc Breau, Bernaudin,Michel Kraemer,

INTRODUCTION: Investigation of the role of vascular endothelial growth factor-C (VEGF-C) and VEGF receptor-3 (VEGFR-3) in non-small-cell lung cancer (NSCLC) has mainly focused on lymph node (LN) metastasis related to lymphangiogenesis. However, the coexpression of VEGF-C/VEGFR-3 by tumour cells can independently play an important role. The present study was therefore designed to evaluate VEGF-C/VEGFR-3 coexpression in tumour cells from the primary tumour and corresponding LN metastases. METHODS: VEGF-C and VEGFR-3 expression in cancer cells were evaluated by immunohistochemistry in 92 NSCLC samples and 45 metastatic LNs. Ki67 expression and mitotic index (MI) in tumours and clinicopathological data were analysed concurrently. RESULTS: VEGFR-3 and VEGF-C expression were observed in 42% and 74% of tumours, respectively. Concurrent expression of VEGF-C and VEGFR-3, observed in 39% of tumours, was significantly associated with a higher proliferation rate and a higher incidence of LN metastases. VEGF-C expression in tumour cells was observed in 100% of metastatic LN and VEGF-C/VEGFR-3 coexpression was observed in 71% of metastatic LN. Finally, concurrent expression of VEGF-C/VEGFR-3 in the primary tumour was associated with poor disease-free survival on univariate analysis. CONCLUSION: In NSCLC cancer cells, VEGF-C/VEGFR-3 coexpression suggests an autocrine/paracrine loop responsible for a high proliferation rate in tumour cells. As VEGF-C/VEGFR-3 coexpression is very frequent in metastatic LN tumour cells, it can be hypothesised that this coexpression participates in the growth of LN metastasis.

Vascular endothelial growth factor-C and its receptor VEGFR-3 in non-small-cell lung cancer: concurrent expression in cancer cells from primary tumour and metastatic lymph node. Publishing Authors By Initials

P Saintigny,M Kambouchner,M Ly,N Gomes,O Sainte-Catherine,R Vassy,S Czernichow,P Letoumelin,JL Breau,JF Bernaudin,M Kraemer,P Saintigny,M Kambouchner,M Ly,N Gomes,O Sainte-Catherine,R Vassy,S Czernichow,P Letoumelin,JL Breau,JF Bernaudin,M Kraemer,P Saintigny,M Kambouchner,M Ly,N Gomes,O Sainte-Catherine,R Vassy,S Czernichow,P Letoumelin,JL Breau,JF Bernaudin,M Kraemer,

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Vascular endothelial growth factor-C and its receptor VEGFR-3 in non-small-cell lung cancer: concurrent expression in cancer cells from primary tumour and metastatic lymph node. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Lung cancer (Amsterdam, Netherlands)

VOLUME: 58

Page Numbers: 205-13

Journal Abbreviation: Lung Cancer

ISSN: 0169-5002

DAY: 7

MONTH: 08

YEAR: 2007

Vascular endothelial growth factor-C and its receptor VEGFR-3 in non-small-cell lung cancer: concurrent expression in cancer cells from primary tumour and metastatic lymph node. Information

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LANGUAGE: eng

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AFFILIATION: Laboratoire d'Oncologie Cellulaire et Moléculaire, EA 3410, Université Paris 13, Bobigny, France. pierre.saintigny@avc.ap-hop-paris.fr

Country: Ireland

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MEDLINETA: Lung Cancer

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