Vascular endothelial growth factor and dexamethasone release from nonfouling sensor coatings affect the foreign body response.

Vascular endothelial growth factor and dexamethasone release from nonfouling sensor coatings affect the foreign body response. Research Abstract Details 

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Vascular endothelial growth factor and dexamethasone release from nonfouling sensor coatings affect the foreign body response. Abstract Text:

L W Norton,H E Koschwanez,N A Wisniewski,B Klitzman,W M Reichert,

Vascular endothelial growth factor (VEGF) and dexamethasone (DX) release from hydrogel coatings were examined as a means to modify tissue inflammation and induce angiogenesis. Antibiofouling hydrogels for implantable glucose sensor coatings were prepared from 2-hydroxyethyl methacrylate, N-vinyl pyrrolidinone, and polyethylene glycol. Microdialysis sampling was used to test the effect of the hydrogel coating on glucose recovery. VEGF-releasing hydrogel-coated fibers increased vascularity and inflammation in the surrounding tissue after 2 weeks of implantation compared to hydrogel-coated fibers. DX-releasing hydrogel-coated fibers reduced inflammation compared to hydrogel-coated fibers and had reduced capsule vascularity compared to VEGF-releasing hydrogel-coated fibers. Hydrogels that released both VEGF and DX simultaneously also showed reduced inflammation at 2 weeks implantation; however, no enhanced vessel formation was observed indicating that the DX diminished the VEGF effect. At 6 weeks, there were no detectable differences between drug-releasing hydrogel-coated fibers and control fibers. From this study, hydrogel drug release affected initial events of the foreign body response with DX inhibiting VEGF, but once the drug depot was exhausted these effects disappeared.

Vascular endothelial growth factor and dexamethasone release from nonfouling sensor coatings affect the foreign body response. Publishing Authors By Initials

LW Norton,HE Koschwanez,NA Wisniewski,B Klitzman,WM Reichert,

For similar peptides: intercellular signaling peptides and proteins: angiogenic proteins: vascular endothelial growth factors: vascular endothelial growth factor a research abstracts see: peptides: intercellular signaling peptides and proteins: angiogenic proteins: vascular endothelial growth factors: vascular endothelial growth factor a research

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MEDLINE DATE:

Vascular endothelial growth factor and dexamethasone release from nonfouling sensor coatings affect the foreign body response. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biomedical materials research. Part A

VOLUME: 81

Page Numbers: 858-69

Journal Abbreviation:

ISSN: 1549-3296

DAY: 15

MONTH: Jun

YEAR: 2007

Vascular endothelial growth factor and dexamethasone release from nonfouling sensor coatings affect the foreign body response. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101234237

Vascular endothelial growth factor and dexamethasone release from nonfouling sensor coatings affect the foreign body response. Keywords Mesh Terms:

KEYWORDS: Vascular Endothelial Growth Factor A

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Vascular endothelial growth factor and dexamethasone release from nonfouling sensor coatings affect the foreign body response. Information

Substance Name: Glucose

Registry Number: 50-99-7

Grant and Affiliation Information for Vascular endothelial growth factor and dexamethasone release from nonfouling sensor coatings affect the foreign body response.

AFFILIATION: Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK54932

ACRONYM: DK

MEDLINETA: J Biomed Mater Res A

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