Vascular deterioration in cirrhosis: the big picture.

Vascular deterioration in cirrhosis: the big picture. Research Abstract Details 

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Vascular deterioration in cirrhosis: the big picture. Abstract Text:

Jaime Bosch,Jaime Bosch,Jaime Bosch,

Cirrhosis is characterized by marked abnormalities in the hepatic circulation. Functionally, there is an increased vascular tone and impaired flow-mediated vasorelaxation, whereas anatomically there is sinusoidal remodeling and capillarization, angiogenesis, venous thrombosis, and vascular distortion, all contributing to increase hepatic vascular resistance and portal hypertension. However, vascular changes are not limited to the liver, but are also present in the splanchnic organs, heart, lungs, kidney, brain, and skin. Advances in the knowledge of the mechanisms of these abnormalities have disclosed new targets for therapy and ultimately improved survival.

Vascular deterioration in cirrhosis: the big picture. Publishing Authors By Initials

J Bosch,J Bosch,J Bosch,

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Vascular deterioration in cirrhosis: the big picture. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of clinical gastroenterology

VOLUME: 41

Page Numbers: S247-53

Journal Abbreviation: J. Clin. Gastroenterol.

ISSN: 0192-0790

DAY: 2

MONTH: 11

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic-Idibaps, University of Barcelona and Centro de Investigación Biomédica de Enfermedades Hepáticas y Digestivas (Ciberehd), Barcelona, Spain.

Country: United States

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MEDLINETA: J Clin Gastroenterol

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