Vascular access outcomes and medication use: a USRDS study.

Vascular access outcomes and medication use: a USRDS study. Research Abstract Details 

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Vascular access outcomes and medication use: a USRDS study. Abstract Text:

Alexander S Yevzlin,Emily L Conley,Robert J Sanchez,Henry N Young,Bryan N Becker,

Several medications have been proposed to improve hemodialysis (HD) vascular access outcomes based on potentially favorable anticoagulant, antiplatelet, or pleiotropic properties. The purpose of this study was to evaluate the relationship between medication use and vascular access patency in a group of HD patients. We conducted a historical cohort study of the US Renal Data System Dialysis Mortality and Morbidity Wave II study to identify patients with an arteriovenous fistula (AVF), polytetrafluoroethylene (PTFE) graft, or a permanent catheter for vascular access. Cox regression analysis, adjusted for age, gender, race, history of coronary artery disease, peripheral vascular disease, or coronary artery bypass graft, was used to model the hazard ratio (HR) of permanent vascular access failure. Of the 2001 HD patients in the Wave II study, 901 (45%) were included in the analysis. PTFE graft patency was greater for males (HR, 0.73; 95% CI 0.53-1.00, p = 0.05) and for older individuals (HR, 0.99; 95% CI 0.98-1.00, p = 0.02). Treatment with antiplatelet medications, ticlopidine and dipyridamole (HR, 3.54; 95% CI 1.07-11.76; p = 0.04), or aspirin (HR, 2.49; 95% CI 1.31-4.73; p = 0.005) was associated with significantly worse AVF patency. Antiplatelet agents had a significant negative association with access patency in this cohort. In contrast to other published data, it was difficult to identify any beneficial effect of specific medications on access patency.

Vascular access outcomes and medication use: a USRDS study. Publishing Authors By Initials

AS Yevzlin,EL Conley,RJ Sanchez,HN Young,BN Becker,

For similar circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic phenomena: vascular patency research abstracts see: circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic phenomena: vascular patency research

PUBMED ID PMID:

MEDLINE DATE:

Vascular access outcomes and medication use: a USRDS study. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Seminars in dialysis

VOLUME: 19

Page Numbers: 535-9

Journal Abbreviation:

ISSN: 0894-0959

DAY: 3

MONTH: 12

YEAR: 2007

Vascular access outcomes and medication use: a USRDS study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8911629

Vascular access outcomes and medication use: a USRDS study. Keywords Mesh Terms:

KEYWORDS: Vascular Patency

MESH TERMS: drug effects

Chemical & Substance for Abstract: Vascular access outcomes and medication use: a USRDS study. Information

Substance Name: Polytetrafluoroethylene

Registry Number: 9002-84-0

Grant and Affiliation Information for Vascular access outcomes and medication use: a USRDS study.

AFFILIATION: School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53713, USA. asy@medicine.wisc.edu

Country: United States

AGENCY: United States NIDDK

GRANT: 1K24DK616962-04

ACRONYM: DK

MEDLINETA: Semin Dial

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