Vascular 131I-low-density lipoprotein imaging in patients with hypertension and early atherosclerotic lesions in the carotid artery.

Vascular 131I-low-density lipoprotein imaging in patients with hypertension and early atherosclerotic lesions in the carotid artery. Research Abstract Details 

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Vascular 131I-low-density lipoprotein imaging in patients with hypertension and early atherosclerotic lesions in the carotid artery. Abstract Text:

G Lupattelli,D Siepi,B Palumbo,L Fedeli,G Ciuffetti,R Palumbo,H Sinzinger,E Mannarino,

BACKGROUND: The reinjection of autologous 131I-labelled low-density lipoprotein (LDL) followed by vascular scintigraphy has been used to investigate lipid-containing plaques, but no information is available on the early stages of plaques in hypertensives. Vascular scintigraphy after re-injection of autologous 131I-labelled LDL was used to investigate early atherosclerotic lesions visualized by sonography in the carotid arteries of patients with hypertension. PATIENTS AND METHODS: 10 male patients (4 smokers; mean age 56 +/- 8 years;) with early carotid atherosclerosis (mono- or bilateral; intima-media-thickness ranging from 1.5 to 3.5 mm) as shown by sonography were studied. All these normolipemic patients suffered from primary hypertension and were treated with diuretics. As controls 6 healthy male subjects (3 smokers; mean age 54 +/- 9 years;), with normal blood pressure and lipid pattern were recruited. RESULTS: Hot spots appeared in the areas with early atherosclerosis in 7 patients, while none were seen in controls. Positive kinetic curves were observed in 4 patients. No significant differences emerged in the target/non-target ratios. CONCLUSIONS: Vascular lipoprotein uptake in hypertensive patients is apparently late and rather limited; the uptake pattern may depend on plaque composition.

Vascular 131I-low-density lipoprotein imaging in patients with hypertension and early atherosclerotic lesions in the carotid artery. Publishing Authors By Initials

G Lupattelli,D Siepi,B Palumbo,L Fedeli,G Ciuffetti,R Palumbo,H Sinzinger,E Mannarino,

For similar behavior and behavior mechanisms: behavior: habits: smoking research abstracts see: behavior and behavior mechanisms: behavior: habits: smoking research

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Vascular 131I-low-density lipoprotein imaging in patients with hypertension and early atherosclerotic lesions in the carotid artery. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: VASA. Zeitschrift für Gefässkrankheiten. Journal f

VOLUME: 28

Page Numbers: 185-9

Journal Abbreviation: VASA

ISSN: 0301-1526

DAY: 13

MONTH: Aug

YEAR: 1999

Vascular 131I-low-density lipoprotein imaging in patients with hypertension and early atherosclerotic lesions in the carotid artery. Information

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LANGUAGE: eng

NlmUniqueID: 317051

Vascular 131I-low-density lipoprotein imaging in patients with hypertension and early atherosclerotic lesions in the carotid artery. Keywords Mesh Terms:

KEYWORDS: Smoking

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Vascular 131I-low-density lipoprotein imaging in patients with hypertension and early atherosclerotic lesions in the carotid artery. Information

Substance Name: Lipoproteins, LDL

Registry Number: 0

Grant and Affiliation Information for Vascular 131I-low-density lipoprotein imaging in patients with hypertension and early atherosclerotic lesions in the carotid artery.

AFFILIATION: Department of Clinical and Experimental Medicine-Internal Medicine, Angiology and Atherosclerosis, University of Perugia, Italy.

Country: SWITZERLAND

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MEDLINETA: Vasa

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