Variation in pleiotropy and the mutational underpinnings of the G-matrix.

Variation in pleiotropy and the mutational underpinnings of the G-matrix. Research Abstract Details 

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Variation in pleiotropy and the mutational underpinnings of the G-matrix. Abstract Text:

Suzanne Estes,Patrick C Phillips,

The pattern and extent of pleiotropic gene action can contribute substantially to the internal structure and shape of the additive genetic variance-covariance matrix (G)--a key determinant of evolutionary trajectories. We use data from our study (Estes et al. 2004) on the univariate effects of mutation in a mismatch-repair-defective strain, msh-2, of Caenorhabditis elegans to address the impact of increasing levels of selection on the magnitude and pattern of genetic covariance due to new mutations. Mutational covariances between three life-history traits are shown to exhibit a weak pattern of decline with increasing population size (increasing selection), while the orientation of mutational matrices remains reasonably constant. This suggests that mutations with smaller effects on fitness may tend to be slightly more confined in their influence than large-effect mutations (i.e., small-effect mutations reduce the magnitude of covariation between characters), but do not change the direction of this covariation.

Variation in pleiotropy and the mutational underpinnings of the G-matrix. Publishing Authors By Initials

S Estes,PC Phillips,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Variation in pleiotropy and the mutational underpinnings of the G-matrix. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Evolution; international journal of organic evolut

VOLUME: 60

Page Numbers: 2655-60

Journal Abbreviation: Evolution

ISSN: 0014-3820

DAY: 3

MONTH: Dec

YEAR: 2006

Variation in pleiotropy and the mutational underpinnings of the G-matrix. Information

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LANGUAGE: eng

NlmUniqueID: 373224

Variation in pleiotropy and the mutational underpinnings of the G-matrix. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

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Grant and Affiliation Information for Variation in pleiotropy and the mutational underpinnings of the G-matrix.

AFFILIATION: Department of Biology, Portland State University, Portland, Oregon 97201, USA. estess@pdx.edu

Country: United States

AGENCY: United States NIGMS

GRANT: GM54185

ACRONYM: GM

MEDLINETA: Evolution Int J Org Evolution

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