Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma.

Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma. Abstract Text:

Sarah E Daugherty,Elizabeth A Platz,Yin Yao Shugart,M Daniele Fallin,William B Isaacs,Nilanjin Chatterjee,Robert Welch,Wen-Yi Huang,Richard B Hayes,

BACKGROUND: alpha-Methylacyl-CoA racemase (AMACR), an enzyme involved in oxidation of branched chain fatty acids and cholesterol metabolites, as well as ibuprofen metabolism, is overexpressed in colorectal adenomas and cancer. AMACR gene variants have been associated with hereditary prostate cancer, but no studies have evaluated their etiologic role in colorectal carcinogenesis. METHODS: We conducted a case-control study of 725 advanced distal colorectal adenoma cases and 729 frequency-matched controls from the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Seven AMACR polymorphisms were genotyped. Unconditional logistic regression models were used to evaluate the associations adjusting for age at randomization and gender. RESULTS: The 201L allele of S201L [TT versus CC: odds ratio (OR), 1.74; 95% confidence interval (95% CI), 1.15-2.62; TC versus CC: OR, 1.17; 95% CI, 0.93-1.49] and the 277E allele of K277E (GG versus AA: OR, 1.66; 95% CI, 1.03-2.68; GA versus AA: OR, 1.21; 95% CI, 0.96-1.53) were associated with increased risk of advanced distal colorectal adenoma (both P(trend)

Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma. Publishing Authors By Initials

SE Daugherty,EA Platz,YY Shugart,MD Fallin,WB Isaacs,N Chatterjee,R Welch,WY Huang,RB Hayes,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

PUBMED ID PMID:

MEDLINE DATE:

Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: Cancer epidemiology, biomarkers & prevention : a p

VOLUME: 16

Page Numbers: 1536-42

Journal Abbreviation: Cancer Epidemiol. Biomarkers P

ISSN: 1055-9965

DAY: 3

MONTH: Aug

YEAR: 2007

Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9200608

Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

Chemical & Substance for Abstract: Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma. Information

Substance Name: alpha-methylacyl-CoA racemase

Registry Number: EC 5.1.99.4

Grant and Affiliation Information for Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma.

AFFILIATION: Divison of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, 6120 Executive Boulevard, EPS Rm 8113, Bethesda, MD 20892, USA. daughers@mail.nih.gov

Country: United States

AGENCY: United States NCI

GRANT: T32 CA09314

ACRONYM: CA

MEDLINETA: Cancer Epidemiol Biomarkers Pr

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma Related Publications

• 1,25-dihydroxyvitamin D3 reverses experimental autoimmune encephalomyelitis by inhibiting chemokine synthesis and monocyte trafficking.
• Administering pneumococcal vaccine.
• An immunohistological study of anhydrous topical ascorbic acid compositions on ex vivo human skin.
• Clinical significance of alphaII-spectrin breakdown products in cerebrospinal fluid after severe traumatic brain injury.
• Detection of interactions between nucleosome arrays mediated by specific core histone tail domains.
• Divalproex utility in bipolar disorder with co-occurring cocaine dependence: a pilot study.
• Effect of D, alpha-tocopheryl succinate and polyethylene glycol on performance tests after fluid percussion brain injury.
• Effects of testosterone and 5alpha-dihydrotestosterone on luteal lifespan in dairy heifers.
• Embattled and embittered or empowered and evolving: Nurse practitioner attitudes toward managed care.
• Environmental process descriptors for TNT, TNT-related compounds and picric acid in marine sediment slurries.
• Front-line osteopathic medicine.
• Histone dynamics during transcription: exchange of H2A/H2B dimers and H3/H4 tetramers during pol II elongation.
• IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis.
• Induction of COX-2 by acrolein in rat lung epithelial cells.
• Influence of drought and municipal sewage effluents on the baseflow water chemistry of an upper piedmont river.
• Phagocytosis of breast cancer cells mediated by anti-MUC-1 monoclonal antibody, DF3, and its bispecific antibody.
• Physical methods used to study core histone tail structures and interactions in solution.
• Porcine mannan-binding lectin A binds to Actinobacillus suis and Haemophilus parasuis.
• Quantifying HIV-1 transmission due to contaminated injections.
• Reviewing and improving a clinical effectiveness department's quality assurance model: lessons learned.
• Seizing-or making-opportunities.
• Stride width discriminates gait of side-fallers compared to other-directed fallers during overground walking.
• Teaching young nonverbal children with autism useful speech: a pilot study of the Denver Model and PROMPT interventions.
• The H3 tail domain participates in multiple interactions during folding and self-association of nucleosome arrays.
• The core histone tail domains contribute to sequence-dependent nucleosome positioning.
• The longevity of amalgam versus compomer/composite restorations in posterior primary and permanent teeth: findings From the New England Children's Amalgam Trial.
• This issue.
• Uses and abuses of tumor markers in the diagnosis, monitoring, and treatment of primary and metastatic breast cancer.
• Validation of a bulk tank milk antibody ELISA to detect dairy herds likely infected with bovine viral diarrhoea virus in New Zealand.
• Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma.