Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV.

Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV. Research Abstract Details 

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Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV. Abstract Text:

Vanessa Rivera-Amill,Richard J Noel,Suheydi Orsini,Griselle Tirado, ,Shilpa Buch,Anil Kumar,

We analyzed the association between the evolution of the V3-V5 regions of env and disease progression in our SIV/SHIV macaque model of morphine dependence and AIDS. Previous studies revealed two distinct disease patterns--fast progression and normal progression. To determine the effect of the two distinct patterns of disease in the evolution of SIV/17E-Fr envelope, we analyzed env sequences from three morphine-dependent macaques that developed accelerated AIDS and three morphine-dependent macaques that developed AIDS at a slower rate and compared them to control macaques. Morphine-dependent animals exhibited a higher percentage of diversity in both plasma and CSF compartments within V4 when compared to controls. Divergence from the inoculum was significantly greater in the morphine group as compared to controls in CSF but not in plasma. We also found a direct correlation in V4 evolution and rapid disease progression. These results indicate that morphine dependence plays a role in the pathogenesis of SIV/SHIV infection and env evolution.

Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV. Publishing Authors By Initials

V Rivera-Amill,RJ Noel,S Orsini,G Tirado,JM ,S Buch,A Kumar,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Virology

VOLUME: 358

Page Numbers: 373-83

Journal Abbreviation: Virology

ISSN: 0042-6822

DAY: 28

MONTH: 09

YEAR: 2006

Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 110674

Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

Chemical & Substance for Abstract: Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV. Information

Substance Name: Morphine

Registry Number: 57-27-2

Grant and Affiliation Information for Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV.

AFFILIATION: AIDS Research Program, Ponce School of Medicine, Ponce, PR 00732, Puerto Rico. vrivera@psm.edu <vrivera@psm.edu>

Country: United States

AGENCY: United States NIDA

GRANT: DA015013

ACRONYM: DA

MEDLINETA: Virology

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ACCESSION NUMBER: DQ785100

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