Variable intensity of purifying selection on cytotoxic T-lymphocyte epitopes in hepatitis C virus.

Variable intensity of purifying selection on cytotoxic T-lymphocyte epitopes in hepatitis C virus. Research Abstract Details 

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Variable intensity of purifying selection on cytotoxic T-lymphocyte epitopes in hepatitis C virus. Abstract Text:

Austin L Hughes,Mary Ann K Hughes,Robert Friedman,

In an analysis of the patterns of nucleotide diversity in 26 datasets providing population-level data on different genomic regions of different hepatitis C virus (HCV) subtypes, known cytotoxic T-lymphocyte (CTL) epitope regions in most cases showed evidence of the occurrence of purifying selection. Two main factors were found to be associated with the strength of purifying selection: (1) purifying selection was stronger in CTL epitopes in non-envelope proteins than in envelope proteins and (2) purifying selection was stronger when the epitope was "matched", i.e., when the described or "canonical" epitope sequence was present unaltered in at least one sequence in the dataset. Of all polymorphic sites, non-synonymous sites in matched CTL epitopes in non-envelope proteins had the lowest gene diversities, implying that these variants are subject to ongoing purifying selection. This in turn suggests that the population frequency of such variants may of be the result of a balance between opposing forces: on the one hand, positive selection favoring escape mutants in hosts that express the presenting MHC molecule and, on the other hand, purifying selection acting, in the absence of the presenting MHC molecule, to reduce the frequency of slightly deleterious variants.

Variable intensity of purifying selection on cytotoxic T-lymphocyte epitopes in hepatitis C virus. Publishing Authors By Initials

AL Hughes,MA Hughes,R Friedman,

For similar proteins: viral proteins research abstracts see: proteins: viral proteins research

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Variable intensity of purifying selection on cytotoxic T-lymphocyte epitopes in hepatitis C virus. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Virus research

VOLUME: 123

Page Numbers: 147-53

Journal Abbreviation: Virus Res.

ISSN: 0168-1702

DAY: 26

MONTH: 09

YEAR: 2006

Variable intensity of purifying selection on cytotoxic T-lymphocyte epitopes in hepatitis C virus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8410979

Variable intensity of purifying selection on cytotoxic T-lymphocyte epitopes in hepatitis C virus. Keywords Mesh Terms:

KEYWORDS: Viral Proteins

MESH TERMS: immunology

Chemical & Substance for Abstract: Variable intensity of purifying selection on cytotoxic T-lymphocyte epitopes in hepatitis C virus. Information

Substance Name: Viral Proteins

Registry Number: 0

Grant and Affiliation Information for Variable intensity of purifying selection on cytotoxic T-lymphocyte epitopes in hepatitis C virus.

AFFILIATION: Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA. austin@biol.sc.edu

Country: Netherlands

AGENCY: United States NIGMS

GRANT: GM43940

ACRONYM: GM

MEDLINETA: Virus Res

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