Vancomycin-intermediate Staphylococcus aureus strains have impaired acetate catabolism: implications for polysaccharide intercellular adhesin synthesis and autolysis.

Vancomycin-intermediate Staphylococcus aureus strains have impaired acetate catabolism: implications for polysaccharide intercellular adhesin synthesis and autolysis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Vancomycin-intermediate Staphylococcus aureus strains have impaired acetate catabolism: implications for polysaccharide intercellular adhesin synthesis and autolysis. Abstract Text:

Jennifer L Nelson,Kelly C Rice,Sean R Slater,Paige M Fox,Gordon L Archer,Kenneth W Bayles,Paul D Fey,Barry N Kreiswirth,Greg A Somerville,

The most common mechanism by which Staphylococcus aureus gains resistance to vancomycin is by adapting its physiology and metabolism to permit growth in the presence of vancomycin. Several studies have examined the adaptive changes occurring during the transition to vancomycin-intermediate resistance, leading to a model of vancomycin resistance in which decreased cell wall turnover and autolysis result in increased cell wall thickness and resistance to vancomycin. In the present study, we identified metabolic changes common to vancomycin-intermediate S. aureus (VISA) strains by assessing the metabolic and growth characteristics of two VISA strains (vancomycin MICs of 8 microg/ml) and two isogenic derivative strains with vancomycin MICs of 32 microg/ml. Interestingly, we observed the parental strains had impaired catabolism of nonpreferred carbon sources (i.e., acetate), and this impairment became more pronounced as vancomycin resistance increased. To determine if acetate catabolism impairment is common to VISA strains, we assessed the ability of VISA and vancomycin-sensitive S. aureus (VSSA) clinical isolates to catabolize acetate. As expected, a significantly greater percentage of VISA strains (71%) had impaired acetate catabolism relative to VSSA (8%). This is an important observation because staphylococcal acetate catabolism is implicated in growth yield and antibiotic tolerance and in regulating cell death and polysaccharide intercellular adhesin synthesis.

Vancomycin-intermediate Staphylococcus aureus strains have impaired acetate catabolism: implications for polysaccharide intercellular adhesin synthesis and autolysis. Publishing Authors By Initials

JL Nelson,KC Rice,SR Slater,PM Fox,GL Archer,KW Bayles,PD Fey,BN Kreiswirth,GA Somerville,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: drug resistance, microbial: drug resistance, bacterial: vancomycin resistance research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: drug resistance, microbial: drug resistance, bacterial: vancomycin resistance research

PUBMED ID PMID:

MEDLINE DATE:

Vancomycin-intermediate Staphylococcus aureus strains have impaired acetate catabolism: implications for polysaccharide intercellular adhesin synthesis and autolysis. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Antimicrobial agents and chemotherapy

VOLUME: 51

Page Numbers: 616-22

Journal Abbreviation: Antimicrob. Agents Chemother.

ISSN: 0066-4804

DAY: 27

MONTH: 11

YEAR: 2006

Vancomycin-intermediate Staphylococcus aureus strains have impaired acetate catabolism: implications for polysaccharide intercellular adhesin synthesis and autolysis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 315061

Vancomycin-intermediate Staphylococcus aureus strains have impaired acetate catabolism: implications for polysaccharide intercellular adhesin synthesis and autolysis. Keywords Mesh Terms:

KEYWORDS: Vancomycin Resistance

MESH TERMS: metabolism

Chemical & Substance for Abstract: Vancomycin-intermediate Staphylococcus aureus strains have impaired acetate catabolism: implications for polysaccharide intercellular adhesin synthesis and autolysis. Information

Substance Name: Vancomycin

Registry Number: 1404-90-6

Grant and Affiliation Information for Vancomycin-intermediate Staphylococcus aureus strains have impaired acetate catabolism: implications for polysaccharide intercellular adhesin synthesis and autolysis.

AFFILIATION: Department of Veterinary and Biomedical Sciences, University of Nebraska, 155 VBS, East Campus Loop, Lincoln, NE 68583-0905, USA.

Country: United States

AGENCY: United States NIAID

GRANT: R01AI038901

ACRONYM: AI

MEDLINETA: Antimicrob Agents Chemother

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Vancomycin-intermediate Staphylococcus aureus strains have impaired acetate catabolism: implications for polysaccharide intercellular adhesin synthesis and autolysis Related Publications

• A long-term follow-up of congenital dislocation of the hip.
• Antipsychotics in individuals with intellectual disability.
• BILE ACID AND CHOLESTEROL METABOLISM.
• Carmustine implants for the treatment of newly diagnosed high-grade gliomas: a cost-utility analysis.
• Development of congenital dislocation of the hip.
• Nonmotile cellulose synthase subunits repeatedly accumulate within localized regions at the plasma membrane in Arabidopsis hypocotyl cells following 2,6-dichlorobenzonitrile treatment.
• Normal and abnormal growth at the upper end of the femur.
• OCULAR LESIONS AFTER TREATMENT WITH CHLOROQUINE.
• Open reduction in congenital dislocation of the hip.
• Out of the blue and into the pink. Is it so rosy for the cardiologist?
• Paralytic dislocation of the hip.
• Persistent foetal alignment of the hip.
• Perthes' disease of the hip.
• Promovision: designing a capacity-building program to strengthen and expand the role of promotores in HIV prevention.
• Results of treatment of 100 congenitally dislocated hips.
• Rotational lordosis; the development of single curve.
• Seizure aggravation by antiepileptic drugs.
• Setting an alert for tick-borne encephalitis.
• Staphylococcus aureus biofilm metabolism and the influence of arginine on polysaccharide intercellular adhesin synthesis, biofilm formation, and pathogenesis.
• Strategies for preventing aspirin-induced gastric bleeding.
• Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta2 agonists for the treatment of chronic asthma in adults and children aged 12 years and over.
• Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta2 agonists for the treatment of chronic asthma in children under the age of 12 years.
• The GRV2/RME-8 protein of Arabidopsis functions in the late endocytic pathway and is required for vacuolar membrane flow.
• The Watcombe Housing Study: the short term effect of improving housing conditions on the health of residents.
• The auricular arrhythmias.
• The paradox of palliative care nursing across cultural boundaries.
• The xenobiotic beta-aminobutyric acid enhances Arabidopsis thermotolerance.
• Two-nail fixation of the hip.
• UNIOCULAR APLASIA OF THE OPTIC NERVE.
• Vancomycin-intermediate Staphylococcus aureus strains have impaired acetate catabolism: implications for polysaccharide intercellular adhesin synthesis and autolysis.