Value of bronchoalveolar lavage before haematopoietic stem cell transplantation for primary immunodeficiency or autoimmune diseases.

Value of bronchoalveolar lavage before haematopoietic stem cell transplantation for primary immunodeficiency or autoimmune diseases. Research Abstract Details 

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Value of bronchoalveolar lavage before haematopoietic stem cell transplantation for primary immunodeficiency or autoimmune diseases. Abstract Text:

M A Slatter,E J Rogerson,C E Taylor,A Galloway,J E Clark,T J Flood,M Abinun,A J Cant,A R Gennery,

Pulmonary infection, often insidious, is frequent in primary immunodeficiency (PID) and acquired immunodeficiency. Pulmonary complications are serious obstacles to success of haematopoietic SCT (HSCT) for these conditions. Bronchoalveolar lavage (BAL) permits identification of lower respiratory tract pathogens that may direct specific treatment and influence prognosis. There are no reports about the utility of pre-HSCT BAL for immunodeficient patients. We prospectively studied the value of 'routine' BAL before commencing transplantation in patients undergoing HSCT for severe immunological disease. Routine non-bronchoscopic BAL was performed under general anaesthetic, a few days before commencing pre-HSCT cytoreductive chemotherapy. Patients were categorized as symptomatic or asymptomatic with respect to pulmonary disease or infection. Samples were sent for microbiological processing. Complications arising from the procedure, pathogens isolated and treatments instituted were recorded. Results were available from 69/75 patients transplanted during the study period; 26 (38%) had pathogens identified (six asymptomatic patients), 10 (14.5%) developed complications post-procedure (two asymptomatic patients)-all recovered, 21 had management changes. There was no statistically significant difference in the number of positive isolates from severe combined or other immunodeficient patients, or of symptomatic or asymptomatic patients. Routine non-bronchoscopic BAL is safe in immunodeficient patients about to undergo HSCT, and leads to management changes.

Value of bronchoalveolar lavage before haematopoietic stem cell transplantation for primary immunodeficiency or autoimmune diseases. Publishing Authors By Initials

MA Slatter,EJ Rogerson,CE Taylor,A Galloway,JE Clark,TJ Flood,M Abinun,AJ Cant,AR Gennery,

For similar congenital, hereditary, and neonatal diseases and abnormalities: infant, newborn, diseases: severe combined immunodeficiency research abstracts see: congenital, hereditary, and neonatal diseases and abnormalities: infant, newborn, diseases: severe combined immunodeficiency research

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Value of bronchoalveolar lavage before haematopoietic stem cell transplantation for primary immunodeficiency or autoimmune diseases. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bone marrow transplantation

VOLUME: 40

Page Numbers: 529-33

Journal Abbreviation: Bone Marrow Transplant.

ISSN: 0268-3369

DAY: 16

MONTH: 07

YEAR: 2007

Value of bronchoalveolar lavage before haematopoietic stem cell transplantation for primary immunodeficiency or autoimmune diseases. Information

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LANGUAGE: eng

NlmUniqueID: 8702459

Value of bronchoalveolar lavage before haematopoietic stem cell transplantation for primary immunodeficiency or autoimmune diseases. Keywords Mesh Terms:

KEYWORDS: Severe Combined Immunodeficiency

MESH TERMS: therapy

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Grant and Affiliation Information for Value of bronchoalveolar lavage before haematopoietic stem cell transplantation for primary immunodeficiency or autoimmune diseases.

AFFILIATION: Department of Paediatric Immunology, Newcastle upon Tyne Hospitals Foundation Trust, Newcastle upon Tyne, UK.

Country: England

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MEDLINETA: Bone Marrow Transplant

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