Validation of a tubular bismuth film amperometric detector. Determination of diclofenac sodium by multisyringe flow injection analysis.

Validation of a tubular bismuth film amperometric detector. Determination of diclofenac sodium by multisyringe flow injection analysis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Validation of a tubular bismuth film amperometric detector. Determination of diclofenac sodium by multisyringe flow injection analysis. Abstract Text:

,Enrique Barrado,Yolanda Castrillejo,J Rodrigo Santos, Lima,

A tubular bismuth film electrode (BFE), installed as part of a multisyringe flow injection system, was used as an amperometric detector to determine the concentration of diclofenac sodium in pharmaceutical formulations. A tubular voltammetric detection cell was employed, in which the hydrodynamic flow conditions were not disturbed. This automated method allows the continuous regeneration of the BFE, preventing passivation of the detector and improving the sensitivity of detection. The influence of several variables on this sensitivity, such as the injection volume, deposition time and flow rate were evaluated; a two-level factorial experimental design was employed for this. In optimal conditions, the linear range of the calibration curve varied from 6.0-50.0 micromol L(-1), with a detection limit of 4.3 micromol L(-1). A sampling rate of 90 determinations/h was achieved; the relative standard deviation of analytical repeatability was <3.5%. After 30 injections the bismuth film on the electrode surface was automatically renewed. The method was validated by comparing the results obtained with those provided by RP-HPLC; no significant difference were seen (p<0.05).

Validation of a tubular bismuth film amperometric detector. Determination of diclofenac sodium by multisyringe flow injection analysis. Publishing Authors By Initials

JA ,E Barrado,Y Castrillejo,JR Santos,JL Lima,

For similar pharmaceutical preparations research abstracts see: pharmaceutical preparations research

PUBMED ID PMID:

MEDLINE DATE:

Validation of a tubular bismuth film amperometric detector. Determination of diclofenac sodium by multisyringe flow injection analysis. Journal Published:

PUBLICATION TYPE: Validation Studies

Journal: Journal of pharmaceutical and biomedical analysis

VOLUME: 45

Page Numbers: 47-53

Journal Abbreviation:

ISSN: 0731-7085

DAY: 25

MONTH: 05

YEAR: 2007

Validation of a tubular bismuth film amperometric detector. Determination of diclofenac sodium by multisyringe flow injection analysis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8309336

Validation of a tubular bismuth film amperometric detector. Determination of diclofenac sodium by multisyringe flow injection analysis. Keywords Mesh Terms:

KEYWORDS: Pharmaceutical Preparations

MESH TERMS: standards

Chemical & Substance for Abstract: Validation of a tubular bismuth film amperometric detector. Determination of diclofenac sodium by multisyringe flow injection analysis. Information

Substance Name: Bismuth

Registry Number: 7440-69-9

Grant and Affiliation Information for Validation of a tubular bismuth film amperometric detector. Determination of diclofenac sodium by multisyringe flow injection analysis.

AFFILIATION: Centro de Investigaciones Quimicas, Universidad Autonoma del Estado de Hidalgo, Carr. Pachuca-Tulancingo km 4.5, 42060 Pachuca, Hidalgo, Mexico. jara78@qa.uva.es

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Pharm Biomed Anal

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Validation of a tubular bismuth film amperometric detector Determination of diclofenac sodium by multisyringe flow injection analysis Related Publications

• A phase II study of irinotecan, high-dose 24-h continuous intravenous infusion of floxuridine and leucovorin (IFLUX) for advanced, previously untreated colorectal cancer.
• Augmentation strategies for treatment-resistant depression: a literature review.
• Beta-blockers and benzodiazepines location in SDS and bile salt micellar systems. An ESR study.
• Clinical outcome of renal transplant patients after coronary stenting.
• Comparative study of a portable system for prothrombin monitoring using capillary blood against venous blood measurements in patients using oral anticoagulants: correlation and concordance.
• DRG11 immunohistochemical expression during embryonic development in the mouse.
• Elevated homocysteine is associated with reduced regional left ventricular function: the Multi-Ethnic Study of Atherosclerosis.
• Evaluation of the "spasticity of conjugate gaze phenomenon" in unilateral cerebral lesions.
• From neuroanatomy to gene therapy: searching for new ways to manipulate the supraspinal endogenous pain modulatory system.
• Genotype testing and antiretroviral resistance profiles from HIV-1 patients experiencing therapeutic failure in northeast Brazil.
• High dietary sodium intake increases white adipose tissue mass and plasma leptin in rats.
• Infectious diseases, balanced polymorphisms, and human evolution: a declaration of interdependence.
• Intestinal permeability and malabsorption of rifampin and isoniazid in active pulmonary tuberculosis.
• Postzoster cutaneous pseudolymphoma in a patient with B-cell chronic lymphocytic leukaemia.
• Protocols to manage postoperative pain in neonates and children hospitalized in a surgical ward. Methodological issues and cultural background.
• RNA ligase structures reveal the basis for RNA specificity and conformational changes that drive ligation forward.
• Re: Christian Seitz, Enis Tanovic, Zeljko Kikic, Mazda Memarsadeghi and Harun Fajkovic. Rapid extracorporeal shock wave lithotripsy for proximal ureteral calculi in colic versus noncolic patients. Eur Urol 2007;52:1223-8.
• Serotonin, 5-HT1A serotonin receptors and proliferation of lymphocytes in major depression patients.
• Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates.
• Taurine trophic modulation of goldfish retinal outgrowth and its interaction with the optic tectum.
• The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics.
• The isolated gamma probe technique for sentinel node penile carcinoma detection is unreliable.
• The non-trivial functions of sleep.
• The propeptide of cruzipain--a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F.
• Undernutrition in early life and body composition of adolescent males from a birth cohort study.
• Validation of a tubular bismuth film amperometric detector. Determination of diclofenac sodium by multisyringe flow injection analysis.
• [Antimicrobial activity "in vitro" of calcium hydroxide and tergentol on different concentrations in oral bactéria]
• [Coronary angiography and angioplasty in diabetic patients]
• [Efficacy of fish as predators of Aedes aegypti larvae, under laboratory conditions]
• [Use conditions of boric acid solution in the eye: handling and occurrence of contamination]