Vaginal absorption of insulin in the rat: effect of penetration enhancers on insulin uptake and mucosal histology.

Vaginal absorption of insulin in the rat: effect of penetration enhancers on insulin uptake and mucosal histology. Research Abstract Details 

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Vaginal absorption of insulin in the rat: effect of penetration enhancers on insulin uptake and mucosal histology. Abstract Text:

J L Richardson,L Illum,N W Thomas,

The absorption of insulin across the vaginal mucosa into the systemic circulation was studied in ovariectomized rats given subsequent estrogen treatment. Blood glucose levels were determined as an indirect measure of insulin absorption, and the effect of various enhancers on the hypoglycemic response was investigated. In the absence of any enhancer, no decrease in blood glucose levels was observed after vaginal administration of insulin. However, the coadministration of sodium taurodihydrofusidate, polyoxyethylene-9-lauryl ether, lysophosphatidylcholine, palmitoylcarnitine chloride, and lysophosphatidylglycerol significantly increased hypoglycemia, whereas citric acid had little effect. The histological changes in the vaginal epithelium after treatment with the enhancer systems were variable and often severe. While the efficacy of these compounds in promoting the vaginal absorption of insulin is encouraging, their mechanisms of action and long-term histological effects are yet to be defined.

Vaginal absorption of insulin in the rat: effect of penetration enhancers on insulin uptake and mucosal histology. Publishing Authors By Initials

JL Richardson,L Illum,NW Thomas,

For similar urogenital system: genitalia: genitalia, female: vagina research abstracts see: urogenital system: genitalia: genitalia, female: vagina research

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Vaginal absorption of insulin in the rat: effect of penetration enhancers on insulin uptake and mucosal histology. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pharmaceutical research

VOLUME: 9

Page Numbers: 878-83

Journal Abbreviation: Pharm. Res.

ISSN: 0724-8741

DAY: 22

MONTH: Jul

YEAR: 1992

Vaginal absorption of insulin in the rat: effect of penetration enhancers on insulin uptake and mucosal histology. Information

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LANGUAGE: eng

NlmUniqueID: 8406521

Vaginal absorption of insulin in the rat: effect of penetration enhancers on insulin uptake and mucosal histology. Keywords Mesh Terms:

KEYWORDS: Vagina

MESH TERMS: metabolism

Chemical & Substance for Abstract: Vaginal absorption of insulin in the rat: effect of penetration enhancers on insulin uptake and mucosal histology. Information

Substance Name: Fusidic Acid

Registry Number: 6990-06-3

Grant and Affiliation Information for Vaginal absorption of insulin in the rat: effect of penetration enhancers on insulin uptake and mucosal histology.

AFFILIATION: Department of Pharmaceutical Sciences, University of Nottingham, U.K.

Country: UNITED STATES

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MEDLINETA: Pharm Res

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