Vagal afferent neurons projecting to the stomach and small intestine exhibit multiple N-methyl-D-aspartate receptor subunit phenotypes.

Vagal afferent neurons projecting to the stomach and small intestine exhibit multiple N-methyl-D-aspartate receptor subunit phenotypes. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Vagal afferent neurons projecting to the stomach and small intestine exhibit multiple N-methyl-D-aspartate receptor subunit phenotypes. Abstract Text:

Krzysztof Czaja,Robert C Ritter,Gilbert A Burns,

Previous reports suggest that NMDA receptors participate in control of food intake via vagal afferent neurons that innervate the upper gastrointestinal (GI) tract. While messenger RNA coding for the NR1 NMDA receptor subunit is present in a majority of vagal afferent neurons of nodose ganglia (NG), immunoreactivity for other NMDA receptor subunits (NR2B, NR2C and NR2D) are expressed in more limited subpopulations of vagal afferents. To determine whether vagal afferent neurons that project to the stomach or duodenum exhibit distinct NMDA receptor subunit phenotypes, we examined immunoreactivity (IR) for NMDA receptor NR1, NR2B, NR2C and NR2D subunits in NG neurons that were labeled by injections of the retrograde tracer Fast Blue (FB) into the wall of the stomach or duodenum. FB injections into the fundus or corpus of the stomach labeled comparable numbers of neurons in both the left and right NG, while proximal duodenal injections labeled only neurons of left NG. NR1-IR expression was observed in most neurons innervating the upper GI tract (fundus, 97%; corpus, 95%; duodenum, 98%). Likewise, most neurons that innervated the upper GI tract expressed NR2B-IR (fundus, 98%; corpus, 85%; duodenum, 81%). NR2C-IR was observed in only 52%, 46% and 32% of FB-positive neurons projecting to the fundus, corpus or duodenum respectively, while NR2D-IR occurred in an even more restricted FB-labeled subpopulation (fundus, 13%; corpus, 26%; and duodenum, 18%). Our observations indicate that different subpopulations of vagal afferents express distinct NMDA receptor subunit phenotypes. However, the neuronal distribution of NMDA receptor subunits is not correlated with innervation of either the stomach or duodenum.

Vagal afferent neurons projecting to the stomach and small intestine exhibit multiple N-methyl-D-aspartate receptor subunit phenotypes. Publishing Authors By Initials

K Czaja,RC Ritter,GA Burns,

For similar nervous system: neural pathways: afferent pathways: visceral afferents research abstracts see: nervous system: neural pathways: afferent pathways: visceral afferents research

PUBMED ID PMID:

MEDLINE DATE:

Vagal afferent neurons projecting to the stomach and small intestine exhibit multiple N-methyl-D-aspartate receptor subunit phenotypes. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Brain research

VOLUME: 1119

Page Numbers: 86-93

Journal Abbreviation: Brain Res.

ISSN: 0006-8993

DAY: 20

MONTH: 09

YEAR: 2006

Vagal afferent neurons projecting to the stomach and small intestine exhibit multiple N-methyl-D-aspartate receptor subunit phenotypes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 45503

Vagal afferent neurons projecting to the stomach and small intestine exhibit multiple N-methyl-D-aspartate receptor subunit phenotypes. Keywords Mesh Terms:

KEYWORDS: Visceral Afferents

MESH TERMS: metabolism

Chemical & Substance for Abstract: Vagal afferent neurons projecting to the stomach and small intestine exhibit multiple N-methyl-D-aspartate receptor subunit phenotypes. Information

Substance Name: diamidino compound 253/50

Registry Number: 0

Grant and Affiliation Information for Vagal afferent neurons projecting to the stomach and small intestine exhibit multiple N-methyl-D-aspartate receptor subunit phenotypes.

AFFILIATION: Department of Veterinary, Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, Pullman, WA 99163-6520, USA.

Country: Netherlands

AGENCY: United States NINDS

GRANT: NS-20561

ACRONYM: NS

MEDLINETA: Brain Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Vagal afferent neurons projecting to the stomach and small intestine exhibit multiple N-methyl-D-aspartate receptor subunit phenotypes Related Publications

• Anger expression and pain: an overview of findings and possible mechanisms.
• Association between a leukotriene C4 synthase gene promoter polymorphism and coronary artery calcium in young women: the Muscatine Study.
• Beef cow reproduction as affected by postpartum nutrition and temporary calf removal.
• Biodegradable estradiol microspheres do not affect uterine involution or characteristics of postpartum estrus in mares.
• Comparison of various predictive formulae for the estimation of resting energy expenditure.
• Dynamic performance of accommodating intraocular lenses in a negative feedback control system: a simulation-based study.
• Electronic drop sensing in microfluidic devices: automated operation of a nanoliter viscometer.
• Enhanced protection against malaria by a chimeric merozoite surface protein vaccine.
• Exacerbations in cystic fibrosis. 1: Epidemiology and pathogenesis.
• Fetal development and gestational changes in Bos taurus and Bos indicus genotypes in the tropics.
• Food security and eating well for all in Victoria.
• Gene expression and cell cycle arrest in a rat keratinocyte line exposed to 56Fe ions.
• Human coronavirus-NL63 infection is not associated with acute Kawasaki disease.
• Impressions of Kawasaki syndrome in India.
• Microbiology, safety, and pharmacokinetics of aztreonam lysinate for inhalation in patients with cystic fibrosis.
• Microfluidic pressure sensing using trapped air compression.
• Microstencils for the patterning of nontraditional materials.
• Migration of a gastrostomy tube into the kidney.
• Nanoliter viscometer for analyzing blood plasma and other liquid samples.
• Nanopore sequencing technology: research trends and applications.
• Neuropsychiatric consequences of traumatic brain injury: a comparison between two age groups.
• Optimization of dielectrophoretic DNA stretching in microfabricated devices.
• Palmitate turnover and its response to glucose infusion in weight-losing cancer patients.
• Percutaneous lumbar discectomy with a working endoscope and laser assistance.
• Progesterone and estradiol in biodegradable microspheres for control of estrus and ovulation in mares.
• Stiff-person syndrome.
• The social brain hypothesis of schizophrenia.
• The utilisation of peripherally-administered intravenous nutrient solutions.
• Trait anger and blood pressure recovery following acute pain: evidence for opioid-mediated effects.
• Vagal afferent neurons projecting to the stomach and small intestine exhibit multiple N-methyl-D-aspartate receptor subunit phenotypes.