Vaccine efficacy of an attenuated but persistent Mycobacterium tuberculosis cysH mutant.

Vaccine efficacy of an attenuated but persistent Mycobacterium tuberculosis cysH mutant. Research Abstract Details 

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Vaccine efficacy of an attenuated but persistent Mycobacterium tuberculosis cysH mutant. Abstract Text:

Ryan H Senaratne,Joseph D Mougous,J Rachel Reader,Spencer J Williams,Tianjiao Zhang,Carolyn R Bertozzi,Lee W Riley,

The emergence of drug-resistant Mycobacterium tuberculosis strains and the widespread occurrence of AIDS demand newer and more efficient control of tuberculosis. The protective efficacy of the current Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccine is highly variable. Therefore, development of an effective new vaccine has gained momentum in recent years. Recently, several M. tuberculosis mutants were tested as potential vaccine candidates in the mouse model of tuberculosis. However, only some of these mutants were able to generate protection equivalent to that of BCG in mice. This study reports the vaccine potential of an attenuated 5'-adenosine phosphosulfate reductase mutant (DeltacysH) of M. tuberculosis. Immunization of mice with either BCG or DeltacysH followed by infection with the virulent M. tuberculosis Erdman strain demonstrated that DeltacysH can generate protection equivalent to that of the BCG vaccine.

Vaccine efficacy of an attenuated but persistent Mycobacterium tuberculosis cysH mutant. Publishing Authors By Initials

RH Senaratne,JD Mougous,JR Reader,SJ Williams,T Zhang,CR Bertozzi,LW Riley,

For similar complex mixtures: biological products: vaccines: vaccines, attenuated research abstracts see: complex mixtures: biological products: vaccines: vaccines, attenuated research

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MEDLINE DATE:

Vaccine efficacy of an attenuated but persistent Mycobacterium tuberculosis cysH mutant. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of medical microbiology

VOLUME: 56

Page Numbers: 454-8

Journal Abbreviation: J. Med. Microbiol.

ISSN: 0022-2615

DAY: 3

MONTH: Apr

YEAR: 2007

Vaccine efficacy of an attenuated but persistent Mycobacterium tuberculosis cysH mutant. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 224131

Vaccine efficacy of an attenuated but persistent Mycobacterium tuberculosis cysH mutant. Keywords Mesh Terms:

KEYWORDS: Vaccines, Attenuated

MESH TERMS: immunology

Chemical & Substance for Abstract: Vaccine efficacy of an attenuated but persistent Mycobacterium tuberculosis cysH mutant. Information

Substance Name: Vaccines, Attenuated

Registry Number: 0

Grant and Affiliation Information for Vaccine efficacy of an attenuated but persistent Mycobacterium tuberculosis cysH mutant.

AFFILIATION: School of Public Health, University of California, Berkeley, CA 94720, USA.

Country: England

AGENCY: United States NIAID

GRANT: AI-51622

ACRONYM: AI

MEDLINETA: J Med Microbiol

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