Vaccination with Venezuelan equine encephalitis replicons encoding cowpox virus structural proteins protects mice from intranasal cowpox virus challenge.

Vaccination with Venezuelan equine encephalitis replicons encoding cowpox virus structural proteins protects mice from intranasal cowpox virus challenge. Research Abstract Details 

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Vaccination with Venezuelan equine encephalitis replicons encoding cowpox virus structural proteins protects mice from intranasal cowpox virus challenge. Abstract Text:

Natalie J Thornburg,Caroline A Ray,Martha L Collier,Hua-Xin Liao,David J Pickup,Robert E Johnston,

An anti-poxvirus vaccine based on replicon particles of Venezuelan equine encephalitis virus (VRP) is being developed. The cowpox virus genes encoding structural proteins corresponding to vaccinia virus proteins A33, B5, and A27 were each expressed from VRP. High serum IgG titers against these proteins were generated in BALB/c mice vaccinated with each of these VRP. VRP induced both IgG1 and IgG2a with a strong predominance of IgG2a production. The response is long-lasting, as evidenced by the retention of high anti-B5 serum IgG titers through at least 50 weeks after priming immunization. Mice vaccinated with B5-, A33- or A27-VRP individually or together survived intranasal challenge with cowpox virus, with the multivalent vaccine formulation providing more effective protection from weight loss and clinical signs of illness than the monovalent vaccines. These results demonstrate that VRP may provide an effective alternative to vaccinia virus vaccines against poxvirus infection.

Vaccination with Venezuelan equine encephalitis replicons encoding cowpox virus structural proteins protects mice from intranasal cowpox virus challenge. Publishing Authors By Initials

NJ Thornburg,CA Ray,ML Collier,HX Liao,DJ Pickup,RE Johnston,

For similar complex mixtures: biological products: vaccines: viral vaccines research abstracts see: complex mixtures: biological products: vaccines: viral vaccines research

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Vaccination with Venezuelan equine encephalitis replicons encoding cowpox virus structural proteins protects mice from intranasal cowpox virus challenge. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Virology

VOLUME: 362

Page Numbers: 441-52

Journal Abbreviation: Virology

ISSN: 0042-6822

DAY: 9

MONTH: 02

YEAR: 2007

Vaccination with Venezuelan equine encephalitis replicons encoding cowpox virus structural proteins protects mice from intranasal cowpox virus challenge. Information

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LANGUAGE: eng

NlmUniqueID: 110674

Vaccination with Venezuelan equine encephalitis replicons encoding cowpox virus structural proteins protects mice from intranasal cowpox virus challenge. Keywords Mesh Terms:

KEYWORDS: Viral Vaccines

MESH TERMS: immunology

Chemical & Substance for Abstract: Vaccination with Venezuelan equine encephalitis replicons encoding cowpox virus structural proteins protects mice from intranasal cowpox virus challenge. Information

Substance Name: Viral Vaccines

Registry Number: 0

Grant and Affiliation Information for Vaccination with Venezuelan equine encephalitis replicons encoding cowpox virus structural proteins protects mice from intranasal cowpox virus challenge.

AFFILIATION: Carolina Vaccine Institute, 9th Floor Burnett-Womack, West Drive, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7292, USA. nthornbu@med.unc.edu

Country: United States

AGENCY: United States NIAID

GRANT: 1U54AI057157

ACRONYM: AI

MEDLINETA: Virology

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