Vaccination approaches to combat human metapneumovirus lower respiratory tract infections.

Vaccination approaches to combat human metapneumovirus lower respiratory tract infections. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Vaccination approaches to combat human metapneumovirus lower respiratory tract infections. Abstract Text:

Sander Herfst,Ron A M Fouchier,

Human metapneumovirus (hMPV) was discovered in 2001 as a causative agent of respiratory disease in young children, immunocompromised individuals and the elderly. Clinical signs of hMPV infection range from mild respiratory illness to bronchiolitis and pneumonia. Two main genetic lineages of hMPV that circulate worldwide were found to be antigenically different, but antibodies against the F protein, the major determinant of protection, were shown to be cross-protective. Since the discovery of hMPV in 2001, several research groups have developed vaccine candidates that may be used to protect different risk groups against hMPV-induced respiratory disease. The studies in rodent and non-human primate models look promising, but none of the vaccine candidates has been tested yet in human volunteers. Here we give an overview of the immunogenicity and protective efficacy of a variety of live attenuated, virus vectored, inactivated virus and subunit vaccines that have been tested in animal models.

Vaccination approaches to combat human metapneumovirus lower respiratory tract infections. Publishing Authors By Initials

S Herfst,RA Fouchier,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Vaccination approaches to combat human metapneumovirus lower respiratory tract infections. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of clinical virology : the official public

VOLUME: 41

Page Numbers: 49-52

Journal Abbreviation:

ISSN: 1386-6532

DAY: 4

MONTH: 12

YEAR: 2007

Vaccination approaches to combat human metapneumovirus lower respiratory tract infections. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9815671

Vaccination approaches to combat human metapneumovirus lower respiratory tract infections. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Vaccination approaches to combat human metapneumovirus lower respiratory tract infections. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Vaccination approaches to combat human metapneumovirus lower respiratory tract infections.

AFFILIATION: Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Clin Virol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Vaccination approaches to combat human metapneumovirus lower respiratory tract infections Related Publications

• Antigenic and genetic evolution of swine influenza A (H3N2) viruses in Europe.
• Emerging influenza.
• Generation of temperature-sensitive human metapneumovirus strains that provide protective immunity in hamsters.
• Immunogenicity and efficacy of two candidate human metapneumovirus vaccines in cynomolgus macaques.
• Specificity and functional interaction of the polymerase complex proteins of human and avian metapneumoviruses.
• Vaccination approaches to combat human metapneumovirus lower respiratory tract infections.