Utilization of bronchodilators in ventilated patients without obstructive airways disease.

Utilization of bronchodilators in ventilated patients without obstructive airways disease. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Utilization of bronchodilators in ventilated patients without obstructive airways disease. Abstract Text:

OBJECTIVE: To examine physician practice in, and the costs of, prescribing inhaled bronchodilators to mechanically ventilated patients who do not have obstructive lung disease. METHODS: This was a prospective cohort study at 2 medical intensive care units at 2 tertiary-care academic medical centers, over a 6-month period. Included were the patients who required > or = 24 hours of mechanical ventilation but did not have obstructive lung disease. Excluded were patients who had obstructive lung disease and/or who had undergone > 24 hours of mechanical ventilation outside the study intensive care units. RESULTS: Of the 206 patients included, 74 (36%) were prescribed inhaled bronchodilators without clear indication. Sixty-five of those 74 patients received both albuterol and ipratropium bromide, usually within the first 3 days of intubation (58 patients). Patients prescribed bronchodilators were more hypoxemic; their mean P(aO(2))/F(IO(2)) ratio was lower (188 mm Hg versus 238 mm Hg, p = 0.004), and they were more likely to have pneumonia (53% vs 33%, p = 0.007). The mean extra cost for bronchodilators was 449.35 dollars per patient. Between the group that did receive bronchodilators and the group that did not, there was no significant difference in the incidence of ventilator-associated pneumonia, tracheostomy, or mortality. The incidence of tachyarrhythmias was similar (15% vs 22%, p = 0.25). CONCLUSION: A substantial proportion of mechanically ventilated patients without obstructive lung disease received inhaled bronchodilators.

Utilization of bronchodilators in ventilated patients without obstructive airways disease. Publishing Authors By Initials

For similar health care facilities, manpower, and services: health services: health services misuse: unnecessary procedures research abstracts see: health care facilities, manpower, and services: health services: health services misuse: unnecessary procedures research

PUBMED ID PMID:

MEDLINE DATE:

Utilization of bronchodilators in ventilated patients without obstructive airways disease. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Respiratory care

VOLUME: 52

Page Numbers: 154-8

Journal Abbreviation:

ISSN: 0020-1324

DAY: 3

MONTH: Feb

YEAR: 2007

Utilization of bronchodilators in ventilated patients without obstructive airways disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7510357

Utilization of bronchodilators in ventilated patients without obstructive airways disease. Keywords Mesh Terms:

KEYWORDS: Unnecessary Procedures

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Utilization of bronchodilators in ventilated patients without obstructive airways disease. Information

Substance Name: Ipratropium

Registry Number: 60205-81-4

Grant and Affiliation Information for Utilization of bronchodilators in ventilated patients without obstructive airways disease.

AFFILIATION: Division of Pulmonary and Critical Care Medicine, University of South Carolina, 8 Medical Park, Suite 410, Columbia SC 29203, USA. lchang@gw.mp.sc.edu

Country: United States

AGENCY: United States NHLBI

GRANT: R-T32-HL07106-27

ACRONYM: HL

MEDLINETA: Respir Care

REFSOURCE: Respir Care. 2007 Feb;52(2):152-3

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Utilization of bronchodilators in ventilated patients without obstructive airways disease Related Publications

• A randomized phase 2 trial of bevacizumab with or without daily low-dose interferon alfa-2b in metastatic malignant melanoma.
• Automated ultrasound scanning on a dual-modality breast imaging system: coverage and motion issues and solutions.
• Chondrogenic differentiation on perlecan domain I, collagen II, and bone morphogenetic protein-2-based matrices.
• Coculture with prostate cancer cells alters endoglin expression and attenuates transforming growth factor-beta signaling in reactive bone marrow stromal cells.
• Concurrent malakoplakia of cervical lymph nodes and prostatic adenocarcinoma with bony metastasis: case report.
• Consensus nomenclature: its time has come.
• Effect of Local Iron Irradiation on Mouse Triceps Muscle Morphology: 1903: Board #191 10:30 AM- 10:30 AM.
• Evaluating thin compression paddles for mammographically compatible ultrasound.
• Formation of MUC1 metabolic complex is conserved in tumor-derived and normal epithelial cells.
• Global growth deficiencies in mice lacking the ribosomal protein HIP/RPL29.
• Heparanase expression and function during early pregnancy in mice.
• IFN-alpha-induced signal transduction, gene expression, and antitumor activity of immune effector cells are negatively regulated by suppressor of cytokine signaling proteins.
• Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand.
• Individual trajectories in stress covary with immunity during recovery from cancer diagnosis and treatments.
• Migration of the epidermal over the dermal component (epiboly) in a bilayered bioengineered skin construct.
• Mouse Tibialis Anterior Muscle Mass and Androgen Receptor (AR) expression with Testosterone Manipulation: 1483: Board #246 May 30 9:30 AM - 11:00 AM.
• Myostatin Signaling Alters Adaptation to Functional Overload-Induced Muscle Hypertrophy: 1486: Board #249 May 30 9:30 AM - 11:00 AM.
• Outcomes of prolonged mechanical ventilation.
• Perlecan-stimulated nodules undergo chondrogenic maturation in response to rhBMP-2 treatment in vitro.
• Regional specialization of the cell membrane-associated, polymorphic mucin (MUC1) in human uterine epithelia.
• STAT3 Signaling And Cardiac Enlargement In A Mouse Model Of Chronic Inflammation And Cachexia: 1693: Board #183 May 30 2:00 PM 3:30 PM.
• Skeletal Muscle Apoptosis During Cancer Cachexia in the Apc-/+ Mouse: 1477: Board #240 May 30 9:30 AM - 11:00 AM.
• Spatiotemporal distribution of heparan sulfate epitopes during murine cartilage growth plate development.
• The HF epidemic: the need for new treatment strategies.
• The effects of dietary monensin sodium upon superovulation and embyro viability from mature cows.
• The interference effects of non-rotated versus counter-rotated trials in visuomotor adaptation.
• Transpalatal transsphenoidal approach to the sella in children.
• Ultrasonographic examination and measurement of ram testicles.
• Urological and medical evaluation of men with erectile dysfunction.
• Utilization of bronchodilators in ventilated patients without obstructive airways disease.