Utility of Drug-eluting Stents in Complex Lesions and High-risk Patients.

Utility of Drug-eluting Stents in Complex Lesions and High-risk Patients. Research Abstract Details 

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Utility of Drug-eluting Stents in Complex Lesions and High-risk Patients. Abstract Text:

Eugenia Nikolsky,Gregg W Stone,

Drug-eluting stents represent a breakthrough technology designed to deliver high concentrations of a bioactive agent locally to an atherosclerotic lesion, thereby minimizing systemic side effects of the drug. The safety and efficacy of drug-eluting stents have clearly been demonstrated in noncomplex lesions. This article presents an evidence-based analysis of the current experience with CYPHER sirolimus-eluting stents (Cordis Corp., Miami Lakes, FL) and TAXUS paclitaxel-eluting stents (Boston Scientific, Natick, MA) in a broad spectrum of high-risk and/or complex subsets of patients and lesions, including those with diabetes mellitus, multivessel disease, diffuse disease, very small vessels, lesions in saphenous vein grafts, chronic total occlusions, in-stent restenosis, ostial and bifurcation lesions, unprotected left main disease, and acute myocardial infarction. Emerging data in several of these subsets suggest that drug-eluting stents are safe and effective, and their use may currently be recommended, whereas in other groups of patients and lesions the efficacy and/or safety of drug-eluting stents remains to be determined, thus warranting caution. It is anticipated that penetration of drug-eluting stents will continue to increase, and fewer patients will require surgical revascularization to achieve sustained event-free survival.

Utility of Drug-eluting Stents in Complex Lesions and High-risk Patients. Publishing Authors By Initials

E Nikolsky,GW Stone,

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Utility of Drug-eluting Stents in Complex Lesions and High-risk Patients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current treatment options in cardiovascular medici

VOLUME: 9

Page Numbers: 11-28

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ISSN: 1092-8464

DAY: 23

MONTH: Feb

YEAR: 2007

Utility of Drug-eluting Stents in Complex Lesions and High-risk Patients. Information

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LANGUAGE: eng

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AFFILIATION: Gregg W. Stone, MD Columbia University Medical Center, Herbert Irving Pavilion, 5th Floor, 161 Fort Washington Avenue, New York, NY 10032, USA. gs2184@columbia.edu.

Country: United States

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MEDLINETA: Curr Treat Options Cardiovasc

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