Using Per gene expression to search for photoperiodic oscillators in the hamster suprachiasmatic nucleus.

Using Per gene expression to search for photoperiodic oscillators in the hamster suprachiasmatic nucleus. Research Abstract Details 

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Using Per gene expression to search for photoperiodic oscillators in the hamster suprachiasmatic nucleus. Abstract Text:

Horacio O de la Iglesia,Jennifer Meyer,William J Schwartz,

The circadian pacemaker in the suprachiasmatic nucleus (SCN) is also believed to underlie photoperiodic (seasonal) timekeeping in mammals. This clock has been modeled as a complex pacemaker composed of two coupled circadian oscillators; variability in their mutual phase relationship could account for the ability to measure daylength, with putative morning and evening oscillators synchronized to dawn and dusk, respectively. Recently, several genes have been identified that are believed to be part of the clock's core oscillatory mechanism. Here, we investigate how such molecular oscillations are altered as a function of photoperiod by analyzing Period (Per1, Per2, and Per3) gene expression at the mRNA level using SCN tissue sections and in situ hybridization. Golden hamsters were entrained to complete 24-h light-dark (LD) cycles with either a long (16 h) or a short (8 h) photophase, or they were entrained to the long complete photoperiod and then allowed to free-run in constant darkness. The results show large photoperiod-dependent changes in the duration of high daytime SCN Per1 and Per2 mRNA levels and small changes in the phase difference between their rhythms.

Using Per gene expression to search for photoperiodic oscillators in the hamster suprachiasmatic nucleus. Publishing Authors By Initials

HO de la Iglesia,J Meyer,WJ Schwartz,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Using Per gene expression to search for photoperiodic oscillators in the hamster suprachiasmatic nucleus. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Brain research. Molecular brain research

VOLUME: 127

Page Numbers: 121-7

Journal Abbreviation: Brain Res. Mol. Brain Res.

ISSN: 0169-328X

DAY: 23

MONTH: Aug

YEAR: 2004

Using Per gene expression to search for photoperiodic oscillators in the hamster suprachiasmatic nucleus. Information

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LANGUAGE: eng

NlmUniqueID: 8908640

Using Per gene expression to search for photoperiodic oscillators in the hamster suprachiasmatic nucleus. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

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Substance Name: Transcription Factors

Registry Number: 0

Grant and Affiliation Information for Using Per gene expression to search for photoperiodic oscillators in the hamster suprachiasmatic nucleus.

AFFILIATION: Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.

Country: Netherlands

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MEDLINETA: Brain Res Mol Brain Res

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