[Usefulness of serum alpha-fetoprotein (AFP) as a marker for hepatocellular carcinoma (HCC) in hepatitis C virus related cirrhosis: analysis of the factors influencing AFP elevation without hcc development]

[Usefulness of serum alpha-fetoprotein (AFP) as a marker for hepatocellular carcinoma (HCC) in hepatitis C virus related cirrhosis: analysis of the factors influencing AFP elevation without hcc development] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Usefulness of serum alpha-fetoprotein (AFP) as a marker for hepatocellular carcinoma (HCC) in hepatitis C virus related cirrhosis: analysis of the factors influencing AFP elevation without hcc development] Abstract Text:

Kyung-Ah Kim,June Sung Lee,Eun Sook Jung,Jong Yeon Kim,Won Ki Bae,Nam-Hoon Kim,Young Soo Moon,

BACKGROUND/AIMS: Serum alpha-fetoprotein (AFP) is frequently used for the diagnosis of hepatocellular carcinoma (HCC). Most available data concerning AFP came from studies of patients with chronic hepatitis B or mixed etiologies. Studies concerning the diagnostic value of AFP for HCV-related liver cirrhosis (LC) are limited. We evaluated the factors influencing AFP elevation in the absence of HCC and analyzed the diagnostic value of serum AFP in HCC surveillance of HCV-related LC patients. METHODS: We enrolled 55 patients of HCV-related LC with HCC and 62 patients without HCC as a case-control study were analyzed. The sensitivity and specificity were calculated and the clinical and biochemical factors influencing serum AFP levels. RESULTS: The sensitivities and specificities of serum AFP for the detection of HCC in HCV-related LC were 72.7% and 59.7% for AFP>or=20 ng/mL, and 47.3% and 92.5% for AFP>or=100 ng/mL, respectively. Elevated serum AST was independently associated with elevated serum AFP level in HCV-related LC. In cases of ASTor=100 ng/mL for the diagnosis of HCC was 100%. However, in case of AST>2 ULN, the specificity was 85.0% for AFP>or=100 ng/mL and 95.0% for AFP>or=200 ng/mL. CONCLUSIONS: Serum AST levels influence serum AFP level in HCV-related LC. In cases of AST2 ULN.

[Usefulness of serum alpha-fetoprotein (AFP) as a marker for hepatocellular carcinoma (HCC) in hepatitis C virus related cirrhosis: analysis of the factors influencing AFP elevation without hcc development] Publishing Authors By Initials

KA Kim,JS Lee,ES Jung,JY Kim,WK Bae,NH Kim,YS Moon,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

[Usefulness of serum alpha-fetoprotein (AFP) as a marker for hepatocellular carcinoma (HCC) in hepatitis C virus related cirrhosis: analysis of the factors influencing AFP elevation without hcc development] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Korean journal of gastroenterology = Taehan So

VOLUME: 48

Page Numbers: 321-6

Journal Abbreviation:

ISSN: 1598-9992

DAY: 29

MONTH: Nov

YEAR: 2006

[Usefulness of serum alpha-fetoprotein (AFP) as a marker for hepatocellular carcinoma (HCC) in hepatitis C virus related cirrhosis: analysis of the factors influencing AFP elevation without hcc development] Information

Number of References:

LANGUAGE: kor

NlmUniqueID: 101189416

[Usefulness of serum alpha-fetoprotein (AFP) as a marker for hepatocellular carcinoma (HCC) in hepatitis C virus related cirrhosis: analysis of the factors influencing AFP elevation without hcc development] Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: [Usefulness of serum alpha-fetoprotein (AFP) as a marker for hepatocellular carcinoma (HCC) in hepatitis C virus related cirrhosis: analysis of the factors influencing AFP elevation without hcc development] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Usefulness of serum alpha-fetoprotein (AFP) as a marker for hepatocellular carcinoma (HCC) in hepatitis C virus related cirrhosis: analysis of the factors influencing AFP elevation without hcc development]

AFFILIATION: Department of Internal Medicine, College of Medicine, Inje University, Ilsanpaik Hospital, Ilsan-Gu, Goyang, Korea.

Country: Korea (South)

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Korean J Gastroenterol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Usefulness of serum alpha-fetoprotein AFP as a marker for hepatocellular carcinoma HCC in hepatitis C virus related cirrhosis: analysis of the factors influencing AFP elevation without hcc development Related Publications

• (Ta/Si) multilayer as a wide-bandpass monochromator material.
• A peroxisome proliferator-activated receptor gamma antagonist induces vimentin cleavage and inhibits invasion in high-grade hepatocellular carcinoma.
• Antisense targeting of TGF-beta1 augments BMP-induced upregulation of osteopontin, type I collagen and Cbfa1 in human Saos-2 cells.
• Aqueous extract of Magnolia officinalis mediates proliferative capacity, p21WAF1 expression and TNF-alpha-induced NF-kappaB activity in human urinary bladder cancer 5637 cells; involvement of p38 MAP kinase.
• Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease.
• Determination of eperisone in human plasma by liquid chromatography-ESI-tandem mass spectrometry.
• Estimation of potential health gains from reducing multiple risk factors of stroke in Korea.
• How home care and hospice nurses can assist adolescents when a parent is seriously ill: adolescents with seriously ill family members.
• Hysteroscopic resection of the vaginal septum in uterus didelphys with obstructed hemivagina: a case report.
• Keeping up to date.
• Microcalcification detection in 3-d breast ultrasound.
• Mineralization of phenol by Ce(IV)-mediated electrochemical oxidation in methanesulphonic acid medium: a preliminary study.
• Neuroprotective activity of triterpenoid saponins from Platycodi radix against glutamate-induced toxicity in primary cultured rat cortical cells.
• On-line analysis of a continuous-flow ozonolysis reaction using Raman spectroscopy.
• Performance measurement of the microPET focus 120 scanner.
• Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera.
• Relations between age, weight, refractive error and eye shape by computerized tomography in children.
• Simple and highly efficient synthesis of 3'-deoxy-3'-[18F]fluorothymidine using nucleophilic fluorination catalyzed by protic solvent.
• Stereoselective [2,3]-sigmatropic rearrangements of unstabilized nitrogen ylides.
• System for inducible expression of cre-recombinase from the Foxa2 locus in endoderm, notochord, and floor plate.
• The role of PET/CT for evaluating breast cancer.
• Type I collagen-induced pro-MMP-2 activation is differentially regulated by H-Ras and N-Ras in human breast epithelial cells.
• WNTS and WNT receptors as therapeutic tools and targets in human disease processes.
• [A nationwide survey on current conditions of school health education]
• [Anger, cardiovascular health and depression in middle-aged Korean men: the mediating effect of social support]
• [Expression of caveolin in hepatocellular carcinoma: association with unpaired artery formation and radiologic findings]
• [Health perception, body image, sexual function and depression in menopausal women according to menopausal stages]
• [Renal dysfunction after spontaneous bacterial peritonitis in cirrhosis: incidence and risk factors]
• [Surgical treatment of sclerosing hepatocellular carcinoma]
• [Usefulness of serum alpha-fetoprotein (AFP) as a marker for hepatocellular carcinoma (HCC) in hepatitis C virus related cirrhosis: analysis of the factors influencing AFP elevation without hcc development]