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[Usefulness of chromosome alteration analysis in cell lines derived from laryngeal tumors for evaluation of laryngeal neoplasms]

[Usefulness of chromosome alteration analysis in cell lines derived from laryngeal tumors for evaluation of laryngeal neoplasms] Research Abstract Details 

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  • [Usefulness of chromosome alteration analysis in cell lines derived from laryngeal tumors for evaluation of laryngeal neoplasms] Abstract Text:

    m jarmuzM Jarmuz,k szyfterK Szyfter,r grenmanR Grenman,w golusinskiW Golusinski,w szyfterW Szyfter,

    A classical cytogenetic analysis was applied to analyse karyotypes of 9 cell lines derived from laryngeal cancer. The most frequent aberration was a deletion of the whole sex chromosome Y. An abundance of somatic chromosome alterations was further analysed to find correlation with tumour staging and grading. A conventional cytogenetic analysis seems to be not sufficient to recognize chromosome alterations specific for a given tumor stage. On the other hand, an analysis in respect to histologic grading has indicated for an association between rearrangement of 9 chromosome and a high tumor aggressiveness. It seems that a combination of conventional cytogenetics with molecular methods (FISH, CGH) would be helpful in diagnosing of laryngeal cancer.

    [Usefulness of chromosome alteration analysis in cell lines derived from laryngeal tumors for evaluation of laryngeal neoplasms] Publishing Authors By Initials

    m jarmuzM Jarmuz,k szyfterK Szyfter,r grenmanR Grenman,w golusinskiW Golusinski,w szyfterW Szyfter,

    For similar cells: cellular structures: chromosomes: sex chromosomes: y chromosome research abstracts see: cells: cellular structures: chromosomes: sex chromosomes: y chromosome research

    PUBMED ID PMID:

    MEDLINE DATE:

    [Usefulness of chromosome alteration analysis in cell lines derived from laryngeal tumors for evaluation of laryngeal neoplasms] Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Otolaryngologia polska. The Polish otolaryngology

    VOLUME: 54

    Page Numbers: 567-72

    Journal Abbreviation:

    ISSN: 0030-6657

    DAY: 28

    MONTH: 12

    YEAR: 2000

    [Usefulness of chromosome alteration analysis in cell lines derived from laryngeal tumors for evaluation of laryngeal neoplasms] Information

    Number of References:

    LANGUAGE: pol

    NlmUniqueID: 404453

    [Usefulness of chromosome alteration analysis in cell lines derived from laryngeal tumors for evaluation of laryngeal neoplasms] Keywords Mesh Terms:

    KEYWORDS: Y Chromosome

    MESH TERMS: genetics

    Chemical & Substance for Abstract: [Usefulness of chromosome alteration analysis in cell lines derived from laryngeal tumors for evaluation of laryngeal neoplasms] Information

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    Grant and Affiliation Information for [Usefulness of chromosome alteration analysis in cell lines derived from laryngeal tumors for evaluation of laryngeal neoplasms]

    AFFILIATION: Zak?ad Genetyki Cz?owieka PAN w Poznaniu. maljar@yahoo.com

    Country: Poland

    Poland Research PublicationPoland Research Publication

    AGENCY:

    GRANT:

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    MEDLINETA: Otolaryngol Pol

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