Usefulness and pharmacokinetic study of oral terbinafine for hyperkeratotic type tinea pedis.

Usefulness and pharmacokinetic study of oral terbinafine for hyperkeratotic type tinea pedis. Research Abstract Details 

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Usefulness and pharmacokinetic study of oral terbinafine for hyperkeratotic type tinea pedis. Abstract Text:

Izumi Kikuchi,Hiroyuki Tanuma,Kensuke Morimoto,Seiji Kawana,

To study and establish an optimal administration method of oral antifungal, terbinafine (TBF), for hyperkeratotic type tinea pedis, from the pharmacokinetic point of view, 20 patients with hyperkeratotic type tinea pedis were given TBF 125 mg once daily for 4 weeks and observed over time for improvement in dermatological symptoms and mycological efficacy. Targeting five of the patients, TBF concentration in the stratum corneum was measured using the liquid chromatography/tandem mass spectrometry (LC-MS/MS) method. TBF was detected in the stratum corneum of the sole 1 week after beginning the treatment in some cases and reached its peak 1 week after the completion of the treatment with a concentration of 247.8 ng g(-1), which was approximately more than 50 times higher than its minimal inhibitory concentration against dermatophytes. TBF was not detected at 8 weeks post-treatment, although its concentration was 50.73 ng g(-1) at 6 weeks post-treatment. Its effectiveness rate (effective + markedly effective) was 95% (19/20) with no adverse reactions, including abnormal changes in the laboratory test values, in any patient. These results suggest that TBF is a useful drug to treat hyperkeratotic tinea pedis from the pharmacokinetic point of view.

Usefulness and pharmacokinetic study of oral terbinafine for hyperkeratotic type tinea pedis. Publishing Authors By Initials

I Kikuchi,H Tanuma,K Morimoto,S Kawana,

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Usefulness and pharmacokinetic study of oral terbinafine for hyperkeratotic type tinea pedis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Mycoses

VOLUME: 51

Page Numbers: 7-13

Journal Abbreviation: Mycoses

ISSN: 0933-7407

DAY: 13

MONTH: Jan

YEAR: 2008

Usefulness and pharmacokinetic study of oral terbinafine for hyperkeratotic type tinea pedis. Information

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LANGUAGE: eng

NlmUniqueID: 8805008

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Grant and Affiliation Information for Usefulness and pharmacokinetic study of oral terbinafine for hyperkeratotic type tinea pedis.

AFFILIATION: Department of Dermatology, Nippon Medical School, Tokyo, Japan, and Aidu Chuo Hospital, Fukushima, Japan.

Country: Germany

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MEDLINETA: Mycoses

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