Use of very low-dose naltrexone during opiate detoxification.

Use of very low-dose naltrexone during opiate detoxification. Research Abstract Details 

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Use of very low-dose naltrexone during opiate detoxification. Abstract Text:

The use of antagonist drugs to reduce the duration of opiate detoxification severely enhances withdrawal symptoms. To investigate the feasibility of administering antagonists with opiates without intense withdrawal during detoxification, 5 methadone maintained patients were evaluated while tapering methadone and receiving at the same time very low (0.125 mg), then increasing daily doses of naltrexone in the course of a 6-day, day hospital treatment. Reduced quantities of adjunctive medications were administered, as compared to the standard protocols, the treatment was completed without incidents or particular discomfort and all patients were easily induced to naltrexone maintenance by the day of discharge. Controlled studies will clarify whether very low-dose naltrexone provides a safe and comfortable detoxification technique to reduce withdrawal intensity and duration without the problems of heavy sedation, as suggested by the description of these clinical cases.

Use of very low-dose naltrexone during opiate detoxification. Publishing Authors By Initials

For similar disorders of environmental origin: substance-related disorders: opioid-related disorders research abstracts see: disorders of environmental origin: substance-related disorders: opioid-related disorders research

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Use of very low-dose naltrexone during opiate detoxification. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of addictive diseases

VOLUME: 22

Page Numbers: 63-70

Journal Abbreviation:

ISSN: 1055-0887

DAY: 12

MONTH: 05

YEAR: 2003

Use of very low-dose naltrexone during opiate detoxification. Information

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LANGUAGE: eng

NlmUniqueID: 9107051

Use of very low-dose naltrexone during opiate detoxification. Keywords Mesh Terms:

KEYWORDS: Opioid-Related Disorders

MESH TERMS: rehabilitation

Chemical & Substance for Abstract: Use of very low-dose naltrexone during opiate detoxification. Information

Substance Name: Methadone

Registry Number: 76-99-3

Grant and Affiliation Information for Use of very low-dose naltrexone during opiate detoxification.

AFFILIATION: Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA. pmannelli@katamail.com

Country: United States

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MEDLINETA: J Addict Dis

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