Use of tumor necrosis factor inhibitors in uveitis.

Use of tumor necrosis factor inhibitors in uveitis. Research Abstract Details 

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Use of tumor necrosis factor inhibitors in uveitis. Abstract Text:

C Egla Rabinovich,

PURPOSE OF REVIEW: Use of tumor necrosis factor-alpha blocking agents to treat chronic pediatric uveitis is becoming recognized as an important therapeutic modality. This review summarizes the rationale for this use, highlighting new studies of these agents in pediatric uveitis. RECENT FINDINGS: The majority of patients with pediatric uveitis either have idiopathic uveitis or uveitis associated with juvenile idiopathic arthritis. Ophthalmologic morbidity among these children is common. Most studies evaluating tumor necrosis factor-alpha blockade in pediatric uveitis are retrospective case series, with attendant limitations that are inherent to any retrospective study. Study of uveitis has been hampered by lack of standardization of disease and outcome measures, which has been addressed by uveitis experts with publication of consensus measures. Data to date suggest that tumor necrosis factor-alpha blockade is efficacious in refractory uveitis. Agents with direct tumor necrosis factor-alpha membrane receptor binding activity may be the most efficacious. There remain many unanswered questions in the treatment of pediatric uveitis, including optimal dosing regimen and long-term efficacy. SUMMARY: Tumor necrosis factor-alpha blocking agents play an important role in the treatment of chronic pediatric uveitis. Prospective comparative studies are needed so that we may better understand this role.

Use of tumor necrosis factor inhibitors in uveitis. Publishing Authors By Initials

CE Rabinovich,

For similar eye diseases: uveal diseases: uveitis research abstracts see: eye diseases: uveal diseases: uveitis research

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Use of tumor necrosis factor inhibitors in uveitis. Journal Published:

PUBLICATION TYPE: Review

Journal: Current opinion in rheumatology

VOLUME: 19

Page Numbers: 482-6

Journal Abbreviation:

ISSN: 1040-8711

DAY: 20

MONTH: Sep

YEAR: 2007

Use of tumor necrosis factor inhibitors in uveitis. Information

Number of References: 31

LANGUAGE: eng

NlmUniqueID: 9000851

Use of tumor necrosis factor inhibitors in uveitis. Keywords Mesh Terms:

KEYWORDS: Uveitis

MESH TERMS: drug therapy

Chemical & Substance for Abstract: Use of tumor necrosis factor inhibitors in uveitis. Information

Substance Name: Tumor Necrosis Factor-alpha

Registry Number: 0

Grant and Affiliation Information for Use of tumor necrosis factor inhibitors in uveitis.

AFFILIATION: Division of Pediatric Rheumatology, Duke University Medical Center, Durham, North Carolina 27710, USA. rabin001@mc.duke.edu

Country: United States

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MEDLINETA: Curr Opin Rheumatol

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