Use of selective serotonin reuptake inhibitors and sleep disturbances in community-dwelling older women.

Use of selective serotonin reuptake inhibitors and sleep disturbances in community-dwelling older women. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Use of selective serotonin reuptake inhibitors and sleep disturbances in community-dwelling older women. Abstract Text:

Kristine E Ensrud,Terri L Blackwell,Sonia Ancoli-Israel,Susan Redline,Kristine Yaffe,Susan Diem,David Claman,Katie L Stone, ,

OBJECTIVES: To determine the association between use of selective serotonin reuptake inhibitors (SSRIs) and objective measures of sleep disturbances in older community-dwelling women, including women without evidence of depression. DESIGN: Cross-sectional study. SETTING: Four U.S. clinical centers. PARTICIPANTS: Two thousand eight hundred fifty-three women aged 71 and older (2,630 nonusers of antidepressants and 223 taking SSRIs alone, not in combination with other antidepressants). MEASUREMENTS: Medication use, assessed using an interviewer-administered questionnaire with verification of use from medication containers and computerized dictionary used to categorize type of medication; evidence of depression assessed using self-report or a score of 6 or higher on the Geriatric Depression Scale; and sleep parameters measured using a wrist actigraph, with data collected for an average of four consecutive 24-hour periods. RESULTS: Of the overall cohort of 2,853 women and of 2,337 women without evidence of depression, sleep disturbances were more common in women taking SSRIs than in those not taking antidepressants. After excluding women with evidence of depression and adjusting for multiple potential confounders, women taking SSRIs were more likely to have a sleep duration of 5 hours or less (multivariate odds ratio (MOR)=2.15, 95% confidence interval (CI)=1.04-4.47), sleep efficiency less than 70% (MOR=2.37, 95% CI=1.32-4.25), sleep latency of 1 hour or more (MOR=3.99, 95% CI=2.29-6.96) and eight or more long wake episodes (MOR=1.75, 95% CI=0.99-3.10). CONCLUSION: SSRI use by older women, including those without evidence of depression, is associated with a greater likelihood of sleep disturbances, including poorer sleep efficiency, longer sleep latency, and sleep fragmentation, manifested by multiple long wake episodes. These results add to the uncertainty regarding risks and benefits of SSRI use in aged populations.

Use of selective serotonin reuptake inhibitors and sleep disturbances in community-dwelling older women. Publishing Authors By Initials

KE Ensrud,TL Blackwell,S Ancoli-Israel,S Redline,K Yaffe,S Diem,D Claman,KL Stone, ,

For similar nervous system diseases: sleep disorders research abstracts see: nervous system diseases: sleep disorders research

PUBMED ID PMID:

MEDLINE DATE:

Use of selective serotonin reuptake inhibitors and sleep disturbances in community-dwelling older women. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of the American Geriatrics Society

VOLUME: 54

Page Numbers: 1508-15

Journal Abbreviation:

ISSN: 0002-8614

DAY: 3

MONTH: Oct

YEAR: 2006

Use of selective serotonin reuptake inhibitors and sleep disturbances in community-dwelling older women. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503062

Use of selective serotonin reuptake inhibitors and sleep disturbances in community-dwelling older women. Keywords Mesh Terms:

KEYWORDS: Sleep Disorders

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Use of selective serotonin reuptake inhibitors and sleep disturbances in community-dwelling older women. Information

Substance Name: Serotonin Uptake Inhibitors

Registry Number: 0

Grant and Affiliation Information for Use of selective serotonin reuptake inhibitors and sleep disturbances in community-dwelling older women.

AFFILIATION: Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, and Department of Medicine and Division of Epidemiology, University of Minnesota 55417, USA. ensru001@.umn.edu

Country: United States

AGENCY: United States NIAMS

GRANT: AR35584

ACRONYM: AR

MEDLINETA: J Am Geriatr Soc

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Use of selective serotonin reuptake inhibitors and sleep disturbances in community-dwelling older women Related Publications

• A randomized comparison of the effect of two prelinguistic communication interventions on the acquisition of spoken communication in preschoolers with ASD.
• Ankle injury -football: 1079: may 31 3:35 PM 3:55 PM.
• Base-displaced intercalated structure of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the recognition sequence of the NarI restriction enzyme, a hotspot for -2 bp deletions.
• Characterizing sleep in children with autism spectrum disorders: a multidimensional approach.
• China needs safe and effective microbicides for preventing sexual transmission of HIV.
• Complement factor H polymorphism p.Tyr402His and cuticular Drusen.
• Differential macular and peripheral expression of bestrophin in human eyes and its implication for best disease.
• Drop coating deposition Raman spectroscopy of protein mixtures.
• Eddies in a bottleneck: an arbitrary Debye length theory for capillary electroosmosis.
• Evolutionary change in the insulin receptors of hystricomorph rodents.
• Feasibility and utility of an electronic diary to assess self-report symptoms in patients with inflammatory bowel disease.
• Fibulin-5 distribution in human eyes: relevance to age-related macular degeneration.
• Hepatitis C-related discrimination in New South Wales.
• History of site-tumor conferences at Baylor Sammons Cancer Center.
• Immunostimulatory combinations: designing the next generation of vaccine adjuvants.
• Impact of multivessel disease on reperfusion success and clinical outcomes in patients undergoing primary percutaneous coronary intervention for acute myocardial infarction.
• Incidence of Clostridium difficile infection in inflammatory bowel disease.
• Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenitis): report of a case with other autoimmune manifestations.
• Longitudinal range expansion and cryptic eastern species in the western Palaearctic oak gallwasp, Andricus coriarius.
• Perception and recognition memory of words and werds: two-way mirror effects.
• Power Outputs among Explosive Athletes, Relationships to Maximum Strength, and Strategies for Improvement: 353: 1:40 PM-2:10 PM.
• Prevalence and correlates of periodic limb movements in older women.
• Role of alpha(1)-adrenoceptors of the locus coeruleus in self-stimulation of the medial forebrain bundle.
• Southern Hemisphere humpback whales wintering off Central America: insights from water temperature into the longest mammalian migration.
• Structure of the 1,4-Bis(2'-deoxyadenosin-N(6)-yl)-2S,3S-butanediol intrastrand DNA cross-link arising from butadiene diepoxide in the human N-ras codon 61 sequence.
• Successful use of feedback to improve antibiotic prescribing and reduce Clostridium difficile infection: a controlled interrupted time series.
• Use of selective serotonin reuptake inhibitors and sleep disturbances in community-dwelling older women.
• Using Carey Temperament Scales to assess behavioral style in children with autism spectrum disorders.
• Utility of Drug-eluting Stents in Complex Lesions and High-risk Patients.
• Vitamin D receptor gene polymorphisms and susceptibility M. tuberculosis in Native Paraguayans.