Use of inhaled corticosteroids in pediatric asthma.

Use of inhaled corticosteroids in pediatric asthma. Research Abstract Details 

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Use of inhaled corticosteroids in pediatric asthma. Abstract Text:

Inhaled corticosteroids reduce asthma symptoms and exacerbations, improve lung function, and reduce airway inflammation and bronchial hyperreactivity more effectively than other treatments. However, inhaled corticosteroids may be unable to return lung function and bronchial hyperreactivity to normal when introduced for moderately severe asthma. This finding highlights the need to improve treatment strategy in pediatric asthma. The natural progression of persistent asthma may lead to loss of lung function and chronic bronchial hyperreactivity for children and adults. There is evidence to suggest that asthma acts via a chronic inflammatory process that causes remodeling of the airways with mucosal thickening and smooth muscle hypertrophy. An optimal treatment strategy would be one aimed at reducing the ongoing airway inflammation. Inhaled steroids ameliorate the inflammation, whereas this has not been documented for any other treatment. Delayed introduction of inhaled steroids appears to result in reduced improvement in lung function compared with the early use of inhaled steroids. This improved response from the earlier use of inhaled steroids appears to be valid at any stage of the disease. Therefore, a change in treatment strategy toward earlier introduction of corticosteroids may impede airway remodeling, bronchial hyperreactivity, and airway damage. No other treatment has been found to affect the course of the disease. Systemic side-effects, particularly inhibition of growth in asthmatic children using inhaled corticosteroids, do not seem to be cause for concern. Growth retardation has not been reported when inhaled corticosteroid doses of < or = 400 micrograms daily are individually tailored to each child's needs. The ongoing change in treatment strategy toward the earlier use of inhaled steroids in childhood asthma, as reflected in current revisions of various treatment strategies, therefore seems well founded.

Use of inhaled corticosteroids in pediatric asthma. Publishing Authors By Initials

For similar diagnosis: diagnostic techniques and procedures: diagnostic techniques, respiratory system: respiratory function tests: lung volume measurements research abstracts see: diagnosis: diagnostic techniques and procedures: diagnostic techniques, respiratory system: respiratory function tests: lung volume measurements research

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Use of inhaled corticosteroids in pediatric asthma. Journal Published:

PUBLICATION TYPE: Review

Journal: Pediatric pulmonology. Supplement

VOLUME: 15

Page Numbers: 27-33

Journal Abbreviation:

ISSN: 1054-187X

DAY: 26

MONTH: Sep

YEAR: 1997

Use of inhaled corticosteroids in pediatric asthma. Information

Number of References: 54

LANGUAGE: eng

NlmUniqueID: 9014095

Use of inhaled corticosteroids in pediatric asthma. Keywords Mesh Terms:

KEYWORDS: Lung Volume Measurements

MESH TERMS: drug therapy

Chemical & Substance for Abstract: Use of inhaled corticosteroids in pediatric asthma. Information

Substance Name: Anti-Asthmatic Agents

Registry Number: 0

Grant and Affiliation Information for Use of inhaled corticosteroids in pediatric asthma.

AFFILIATION: Department of Pediatrics, National University Hospital, Copenhagen, Denmark.

Country: UNITED STATES

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MEDLINETA: Pediatr Pulmonol Suppl

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