Use of calcined Mg-Al-hydrotalcite to enhance the stability of celecoxib in the amorphous form.

Use of calcined Mg-Al-hydrotalcite to enhance the stability of celecoxib in the amorphous form. Research Abstract Details 

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Use of calcined Mg-Al-hydrotalcite to enhance the stability of celecoxib in the amorphous form. Abstract Text:

Valeria Ambrogi,Luana Perioli,Fabio Marmottini,Carlo Rossi,Valeria Ambrogi,Luana Perioli,Fabio Marmottini,Carlo Rossi,

The use of compound in amorphous forms is a promising approach to improve solubility of poorly water-soluble drugs. However, during storage, amorphous state can spontaneously transform to the lower energy crystalline form and this is a limiting factor for a large commercial use of drugs. In this paper, calcined hydrotalcite was employed to support amorphous celecoxib and several preparations at different weight drug/carrier ratio were prepared. Solubility of celecoxib from the prepared systems was evaluated and its physical stability during storage at different conditions was examined as well. The results show that HTlc-calc can be used as a support of amorphous celecoxib with consequent improvement of drug solubility and physical stability.

Use of calcined Mg-Al-hydrotalcite to enhance the stability of celecoxib in the amorphous form. Publishing Authors By Initials

V Ambrogi,L Perioli,F Marmottini,C Rossi,V Ambrogi,L Perioli,F Marmottini,C Rossi,

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Use of calcined Mg-Al-hydrotalcite to enhance the stability of celecoxib in the amorphous form. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of pharmaceutics and biopharmaceu

VOLUME: 66

Page Numbers: 253-9

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ISSN: 0939-6411

DAY: 17

MONTH: 10

YEAR: 2006

Use of calcined Mg-Al-hydrotalcite to enhance the stability of celecoxib in the amorphous form. Information

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LANGUAGE: eng

NlmUniqueID: 9109778

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Grant and Affiliation Information for Use of calcined Mg-Al-hydrotalcite to enhance the stability of celecoxib in the amorphous form.

AFFILIATION: Dipartimento di Chimica e Tecnologia del Farmaco, University of Perugia, Perugia, Italy. valeria.ambrogi@unipg.it

Country: Netherlands

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MEDLINETA: Eur J Pharm Biopharm

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