[Use of bicyclol in treatment of chronic hepatitis B virus infection: a systematic review]

[Use of bicyclol in treatment of chronic hepatitis B virus infection: a systematic review] Research Abstract Details 

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[Use of bicyclol in treatment of chronic hepatitis B virus infection: a systematic review] Abstract Text:

Hui-fen Wang,Qiang Li,Pei Lan,

OBJECTIVE: To evaluate the efficacy and safety of bicyclol for chronic hepatitis B. METHOD: The authors searched CBMDisk, CJFD (2000-2006), CJD-CD, PubMed (1966-2006) for randomized controlled trials (RCT) comparing bicyclol versus non-antiviral interventions, interferon alpha (IFN-a) and lamivudine for treatment of chronic hepatitis B. Two reviewers performed data extraction and quality assessment independently and discussed when there was different opinion. We analyzed the data with RevMan 4.2 software supplied by Cochrane Collabration. RESULTS: Fourteen RCTs involving 1782 patients were included. ALT recovery rate of bicyclol group was 69.3 percent while that of the control group was 59.0 percent, the difference was statistical significant [RR 1.24, 95 percent CI (1.01, 1.52), P=0.04]. Loss of HBeAg in the bicyclol group (22.1 percent) was higher than that of the control group (13.5 percent) [RR 1.65, 95 percent CI (1.32, 2.06), P<0.00001]. No serious adverse events were reported. CONCLUSION: Bicyclol might be beneficial to recovery of liver function and loss of serum HBV marker. However, more high quality clinical trials are needed for confirmation.

[Use of bicyclol in treatment of chronic hepatitis B virus infection: a systematic review] Publishing Authors By Initials

HF Wang,Q Li,P Lan,

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[Use of bicyclol in treatment of chronic hepatitis B virus infection: a systematic review] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua shi yan he lin chuang bing du xue za zhi

VOLUME: 21

Page Numbers: 165-7

Journal Abbreviation: Zhonghua Shi Yan He Lin Chuang

ISSN: 1003-9279

DAY: 26

MONTH: Jun

YEAR: 2007

[Use of bicyclol in treatment of chronic hepatitis B virus infection: a systematic review] Information

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LANGUAGE: chi

NlmUniqueID: 9602873

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AFFILIATION: The No. 302 Hospital of the People's Liberation Army, Beijing 100039, China. wanghuifen@medmail.com.cn

Country: China

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MEDLINETA: Zhonghua Shi Yan He Lin Chuang

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