Use of 11p15 mucins as prognostic factors in small adenocarcinoma of the lung.

Use of 11p15 mucins as prognostic factors in small adenocarcinoma of the lung. Research Abstract Details 

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Use of 11p15 mucins as prognostic factors in small adenocarcinoma of the lung. Abstract Text:

Noboru Nishiumi,Yoshiyuki Abe,Yoshimasa Inoue,Hiroyuki Hatanaka,Ken-Ichi Inada,Hiroshi Kijima,Hitoshi Yamazaki,Masae Tatematsu,Yoshito Ueyama,Masayuki Iwasaki,Hiroshi Inoue,Masato Nakamura,

PURPOSE: Patients with small adenocarcinoma of the lung (SACL) generally have a good prognosis. However, some SACL cases show lymph node metastasis, with poor prognosis. The expression pattern of 11p15 mucins (clustered on the p15 arm of the chromosome 11) is known to change during carcinogenesis in lung cancer. EXPERIMENTAL DESIGN: We evaluated the expression of the 11p15 mucins (MUC2, MUC5AC, and MUC6) in 79 surgical specimens of SACL cases by immunohistochemical analysis. Lymph node metastasis was estimated by pathological staging. RESULTS: Six (7.6%) and 11 (13.9%) of the 79 SACL cases showed MUC2 and MUC6 expression, respectively. Three SACL cases showed both MUC2 and MUC6 expression, and a significant correlation was found between MUC2 and MUC6 expression (Fisher's test, P = 0.033). Six (7.6%) SACL cases showed MUC5AC expression. Five of the 6 cases with MUC2 expression and 6 of the 11 cases with MUC6 expression were had lymph node metastasis. SACL cases with MUC2 or MUC6 expression showed a significantly higher incidence of nodal metastasis than those without expression (P < 0.001 and P = 0.006, chi(2) test, respectively). There was no significant correlation between MUC5AC expression and nodal involvement in SACL, whereas three of the six cases with MUC5AC expression showed lymph node metastasis. The SACL cases with MUC2 expression had a significantly poorer prognosis than those without MUC2 expression (P = 0.011, log-rank test). CONCLUSIONS: These results suggest that 11p15 mucins MUC2 and MUC6 are related to lymph node metastasis in SACL.

Use of 11p15 mucins as prognostic factors in small adenocarcinoma of the lung. Publishing Authors By Initials

N Nishiumi,Y Abe,Y Inoue,H Hatanaka,K Inada,H Kijima,H Yamazaki,M Tatematsu,Y Ueyama,M Iwasaki,H Inoue,M Nakamura,

For similar diagnosis: prognosis research abstracts see: diagnosis: prognosis research

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Use of 11p15 mucins as prognostic factors in small adenocarcinoma of the lung. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical cancer research : an official journal of

VOLUME: 9

Page Numbers: 5616-9

Journal Abbreviation: Clin. Cancer Res.

ISSN: 1078-0432

DAY: 15

MONTH: Nov

YEAR: 2003

Use of 11p15 mucins as prognostic factors in small adenocarcinoma of the lung. Information

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LANGUAGE: eng

NlmUniqueID: 9502500

Use of 11p15 mucins as prognostic factors in small adenocarcinoma of the lung. Keywords Mesh Terms:

KEYWORDS: Prognosis

MESH TERMS: analysis

Chemical & Substance for Abstract: Use of 11p15 mucins as prognostic factors in small adenocarcinoma of the lung. Information

Substance Name: Mucins

Registry Number: 0

Grant and Affiliation Information for Use of 11p15 mucins as prognostic factors in small adenocarcinoma of the lung.

AFFILIATION: Department of General Thoracic Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan.

Country: United States

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MEDLINETA: Clin Cancer Res

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