Use and abuse of exogenous H2O2 in studies of signal transduction.

Use and abuse of exogenous H2O2 in studies of signal transduction. Research Abstract Details 

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Use and abuse of exogenous H2O2 in studies of signal transduction. Abstract Text:

Henry Jay Forman,

The goal of this review is to present a rationale for the use of exogenous H(2)O(2), which has been demonstrated to have both toxicological and physiological signaling roles. Reasons for the use of exogenous application of nontoxic concentrations of H(2)O(2) in model systems and caveats for interpretation of the data obtained will both be presented. Briefly, an argument for the cautious use of the addition of exogenous H(2)O(2) is that, because of the permeability of cell membranes to this neutral small molecule, a concentration that is produced locally and that is necessary for the physiological action can be mimicked. On the other hand, it must be recognized that the addition of an agent or its enzymatic generation in the medium may produce reactions that may not normally occur because the total dose of H(2)O(2) and the concentration of H(2)O(2) in some cellular locations will exceed what is normally achieved even under a pathophysiological state. For this reason, this review will try to provide an unbiased balanced pros- and -cons analysis of this issue.

Use and abuse of exogenous H2O2 in studies of signal transduction. Publishing Authors By Initials

HJ Forman,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

PUBMED ID PMID:

MEDLINE DATE:

Use and abuse of exogenous H2O2 in studies of signal transduction. Journal Published:

PUBLICATION TYPE: Review

Journal: Free radical biology & medicine

VOLUME: 42

Page Numbers: 926-32

Journal Abbreviation: Free Radic. Biol. Med.

ISSN: 0891-5849

DAY: 12

MONTH: 01

YEAR: 2007

Use and abuse of exogenous H2O2 in studies of signal transduction. Information

Number of References: 60

LANGUAGE: eng

NlmUniqueID: 8709159

Use and abuse of exogenous H2O2 in studies of signal transduction. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: drug effects

Chemical & Substance for Abstract: Use and abuse of exogenous H2O2 in studies of signal transduction. Information

Substance Name: Hydrogen Peroxide

Registry Number: 7722-84-1

Grant and Affiliation Information for Use and abuse of exogenous H2O2 in studies of signal transduction.

AFFILIATION: School of Natural Sciences, University of California at Merced, Merced, CA 95344, USA. hjforman@gmail.com

Country: United States

AGENCY: United States NIEHS

GRANT: R01 ES005511-17

ACRONYM: ES

MEDLINETA: Free Radic Biol Med

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