Ursolic acid from the Chinese herb danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells.

Ursolic acid from the Chinese herb danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells. Research Abstract Details 

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Ursolic acid from the Chinese herb danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells. Abstract Text:

Katja Steinkamp-Fenske,Larissa Bollinger,Natalie ,Hui Xu,Ying Yao,Rudolf Bauer,Ulrich ,Huige Li,Katja Steinkamp-Fenske,Larissa Bollinger,Natalie ,Hui Xu,Ying Yao,Rudolf Bauer,Ulrich ,Huige Li,Katja Steinkamp-Fenske,Larissa Bollinger,Natalie ,Hui Xu,Ying Yao,Rudolf Bauer,Ulrich ,Huige Li,

Danshen, the dried root of Salvia miltiorrhiza Bunge (Lamiaceae), is one of the most commonly used traditional Chinese medicines for cardiovascular indications. In EA.hy 926 cells, a cell line derived from human umbilical vein endothelial cells (HUVEC), an aqueous extract of danshen, and also a methanol extract of the plant, increased eNOS promoter activity, eNOS mRNA and protein expression, as well as endothelial NO production. A dichloromethane extract, in contrast, did not change eNOS gene expression. Thus, the active danshen constituent(s) responsible for eNOS upregulation is (are) hydrophilic and/or alcohol-soluble. One such compound is ursolic acid that significantly increased eNOS expression in EA.hy 926 cells and native HUVEC, and enhanced bioactive NO production measured in terms of its cGMP increasing activity. Other tested hydrophilic and alcohol-soluble compounds isolated from danshen had no effect on eNOS expression. Interestingly, ursolic acid also reduced the expression of the NADPH oxidase subunit Nox4 and suppressed the production of reactive oxygen species in human endothelial cells. Upregulation of eNOS and a parallel downregulation of Nox4 lead to an increase in bioactive NO. This in turn could mediate some of the beneficial effects of danshen. Ursolic acid is a prototypical compound responsible for this effect of the plant.

Ursolic acid from the Chinese herb danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells. Publishing Authors By Initials

K Steinkamp-Fenske,L Bollinger,N ,H Xu,Y Yao,R Bauer,U ,H Li,K Steinkamp-Fenske,L Bollinger,N ,H Xu,Y Yao,R Bauer,U ,H Li,K Steinkamp-Fenske,L Bollinger,N ,H Xu,Y Yao,R Bauer,U ,H Li,

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Ursolic acid from the Chinese herb danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Atherosclerosis

VOLUME: 195

Page Numbers: e104-11

Journal Abbreviation: Atherosclerosis

ISSN: 0021-9150

DAY: 3

MONTH: 05

YEAR: 2007

Ursolic acid from the Chinese herb danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells. Information

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LANGUAGE: eng

NlmUniqueID: 242543

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AFFILIATION: Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, D-55131 Mainz, Germany.

Country: Ireland

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MEDLINETA: Atherosclerosis

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